Department of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota.
Department of Cardiovascular Disease, Mayo Clinic, Phoenix, Arizona.
J Clin Hypertens (Greenwich). 2020 Jun;22(6):1083-1089. doi: 10.1111/jch.13877. Epub 2020 May 13.
The present study investigated the impact of 12 weeks of pulsed electromagnetic field (PEMF) therapy on peripheral vascular function, blood pressure (BP), and nitric oxide in hypertensive individuals. Thirty hypertensive individuals (SBP > 130 mm Hg and/or MAP > 100 mm Hg) were assigned to either PEMF group (n = 15) or control group (n = 15). During pre-assessment, participants underwent measures of flow-mediated dilation (FMD), BP, and blood draw for nitric oxide (NO). Subsequently, they received PEMF therapy 3x/day for 12 weeks and, at conclusion, returned to the laboratory for post-assessment. Fifteen participants from the PEMF group and 11 participants from the control group successfully completed the study protocol. After therapy, the PEMF group demonstrated significant improvements in FMD and FMD (normalized to hyperemia), but the control group did not (P = .05 and P = .04, respectively). Moreover, SBP, DBP, and MAP were reduced, but the control group did not (P = .04, .04, and .03, respectively). There were no significant alterations in NO in both groups (P > .05). Twelve weeks of PEMF therapy may improve BP and vascular function in hypertensive individuals. Additional studies are needed to identify the mechanisms by which PEMF affects endothelial function.
本研究旨在探讨 12 周脉冲电磁场（PEMF）治疗对高血压患者外周血管功能、血压（BP）和一氧化氮（NO）的影响。30 名高血压患者（SBP>130mmHg 和/或 MAP>100mmHg）被分为 PEMF 组（n=15）或对照组（n=15）。在评估前，参与者进行了血流介导的扩张（FMD）、BP 和血液一氧化氮（NO）检测。随后，他们接受了为期 12 周的 PEMF 治疗，每天 3 次，治疗结束后返回实验室进行评估。PEMF 组的 15 名参与者和对照组的 11 名参与者成功完成了研究方案。治疗后，PEMF 组的 FMD 和 FMD（相对于充血归一化）显著改善，但对照组没有（P=.05 和 P=.04）。此外，SBP、DBP 和 MAP 降低，但对照组没有（P=.04、.04 和.03）。两组的 NO 均无显著变化（P>.05）。12 周的 PEMF 治疗可能改善高血压患者的 BP 和血管功能。需要进一步的研究来确定 PEMF 影响内皮功能的机制。
