Department of Pediatrics, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
PLoS One. 2020 May 13;15(5):e0231579. doi: 10.1371/journal.pone.0231579. eCollection 2020.
In pregnancy after Roux-en-Y gastric bypass (RYGB), there is increased risk of low birthweight in the offspring. The present study examined how offspring body composition was affected by RYGB.
Mother-newborn dyads, where the mothers had undergone RYGB were included. Main outcome measure was neonatal body composition. Neonatal body composition was assessed by dual-energy X-ray absorptiometry scanning (DXA) within 48 hours after birth. In a statistical model offspring born after RYGB were compared with a reference material of offspring and analyses were made to estimate the effect of maternal pre-pregnancy body mass index (BMI), gestational weight gain, parity, gestational age at birth and newborn sex on newborn body composition. Analyses were made to estimate the impact of maternal weight loss before pregnancy and of other effects of bariatric surgery respectively. The study was performed at a university hospital between October 2012 and December 2013.
We included 25 mother-newborn dyads where the mothers had undergone RYGB and compared them to a reference material of 311 mother-newborn dyads with comparable pre-pregnancy BMI. Offspring born by mothers after RYGB had lower birthweight (335g, p<0.001), fat-free mass (268g, p<0.001) and fat% (2.8%, p<0.001) compared with reference material. Only 2% of the average reduction in newborn fat free mass could be attributed to maternal pre-pregnancy weight loss whereas other effects of RYGB accounted for 98%. Regarding reduction in fat mass 52% was attributed to weight loss and 47% to other effects of surgery.
Offspring born after maternal bariatric surgery, had lower birthweight, fat-free mass and fat percentage when compared with a reference material. RYGB itself and not the pre-pregnancy weight loss seems to have had the greatest impact on fetal growth.
在 Roux-en-Y 胃旁路手术后（RYGB）的妊娠中，后代发生低出生体重的风险增加。本研究检查了 RYGB 如何影响后代的身体成分。
纳入了母亲接受 RYGB 的母婴对。主要观察指标是新生儿的身体成分。新生儿的身体成分通过出生后 48 小时内的双能 X 射线吸收法（DXA）扫描进行评估。在一个统计模型中，与参考材料中的后代相比，对 RYGB 后出生的后代进行了分析，并分析了母体孕前体重指数（BMI）、妊娠体重增加、产次、出生时的胎龄和新生儿性别对新生儿身体成分的影响。还分别分析了母亲孕前体重减轻和减肥手术的其他影响。该研究于 2012 年 10 月至 2013 年 12 月在一所大学医院进行。
我们纳入了 25 对接受 RYGB 的母婴对，并将其与具有相似孕前 BMI 的 311 对母婴对参考材料进行了比较。与参考材料相比，接受 RYGB 后的母亲所生的后代出生体重较低（335g，p<0.001），无脂肪质量较低（268g，p<0.001），脂肪%较低（2.8%，p<0.001）。新生儿无脂肪质量平均减少的 2%可以归因于母体孕前体重减轻，而 RYGB 的其他影响占 98%。关于脂肪量的减少，52%归因于体重减轻，47%归因于手术的其他影响。
与参考材料相比，接受母亲减肥手术后出生的后代出生体重、无脂肪质量和脂肪百分比较低。RYGB 本身而不是孕前体重减轻似乎对胎儿生长有最大影响。
