通过计算机分析鉴定出长链非编码 RNA：WDFY3-AS2、BDNF-AS 和 AFAP1-AS1 是三阴性乳腺癌患者的潜在预后因素。
In silico analyses identify lncRNAs: WDFY3-AS2, BDNF-AS and AFAP1-AS1 as potential prognostic factors for patients with triple-negative breast tumors.
机构信息
Discipline of Oncology, Department of Radiology and Oncology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Laboratory of Molecular Genetics, Center for Translational Research in Oncology, Cancer Institute of São Paulo, São Paulo, Brazil.
出版信息
PLoS One. 2020 May 13;15(5):e0232284. doi: 10.1371/journal.pone.0232284. eCollection 2020.
BACKGROUND
Long non-coding RNAs (lncRNAs) are characterized as having 200 nucleotides or more and not coding any protein, and several been identified as differentially expressed in several human malignancies, including breast cancer.
METHODS
Here, we evaluated lncRNAs differentially expressed in triple-negative breast cancer (TNBC) from a cDNA microarray data set obtained in a previous study from our group. Using in silico analyses in combination with a review of the current literature, we identify three lncRNAs as potential prognostic factors for TNBC patients.
RESULTS
We found that the expression of WDFY3-AS2, BDNF-AS, and AFAP1-AS1 was associated with poor survival in patients with TNBCs. WDFY3-AS2 and BDNF-AS are lncRNAs known to play an important role in tumor suppression of different types of cancer, while AFAP1-AS1 exerts oncogenic activity.
CONCLUSION
Our findings provided evidence that WDFY3-AS2, BDNF-AS, and AFAP1-AS1 may be potential prognostic factors in TNBC development.
背景
长链非编码 RNA（lncRNA）的特征是具有 200 个核苷酸或更多，并且不编码任何蛋白质，并且已经在几种人类恶性肿瘤中，包括乳腺癌中鉴定出几种差异表达的 lncRNA。
方法
在这里，我们从我们之前的研究中获得的 cDNA 微阵列数据集评估了三阴性乳腺癌（TNBC）中差异表达的 lncRNA。我们使用计算机分析结合当前文献综述，确定了三个 lncRNA 作为 TNBC 患者的潜在预后因素。
结果
我们发现 WDFY3-AS2、BDNF-AS 和 AFAP1-AS1 的表达与 TNBC 患者的不良生存相关。WDFY3-AS2 和 BDNF-AS 是已知在不同类型的癌症中发挥肿瘤抑制作用的 lncRNA，而 AFAP1-AS1 则发挥致癌活性。
结论
我们的研究结果提供了证据，表明 WDFY3-AS2、BDNF-AS 和 AFAP1-AS1 可能是 TNBC 发展的潜在预后因素。
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