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结直肠癌患者的临床评估及症状模式

CLINICAL EVALUATION AND PATTERN OF SYMPTOMS IN COLORECTAL CANCER PATIENTS.

作者信息

Mello Marianne Regina Silva Potengy de, Moura Silmara Fernandes, Muzi Camila Drumond, GuimarÃes Raphael Mendonça

机构信息

Universidade Federal do Estado do Rio de Janeiro, Escola de Medicina e Cirurgia, Rio de Janeiro, RJ, Brasil.

Instituto Nacional de Câncer José Alencar Gomes da Silva, Rio de Janeiro, RJ, Brasil.

出版信息

Arq Gastroenterol. 2020 Apr-Jun;57(2):131-136. doi: 10.1590/s0004-2803.202000000-24.

Abstract

BACKGROUND

Colorectal cancer is the third most common type of cancer in the world and the increased survival of the colorectal cancer population is very significant. Thus, it becomes relevant to study the symptoms associated with the progression of the disease and treatment, for proper clinical management.

OBJECTIVE

To describe the clinical and epidemiological profile of colorectal cancer patients and to identify the most prevalent signs and symptoms patterns.

METHODS

Cross-sectional study evaluating the prevalence of symptoms in 348 colorectal cancer patients admitted to a referral oncology hospital. We applied MSAS-BR scale and, through factor analysis with principal componente analysys, we performed the grouping of symptoms.

RESULTS

There was a predominance of men, aged 60 years or older, married, white, with high school, moderately differentiated tumor, stage III/IV disease, colon cancer and no distant metastasis. The most prevalent symptoms were weight loss (67.53%) and the least prevalent were mouth sores (2.01%). The groupings of symptoms established were "fatigue and psychic symptoms", "gastrointestinal symptoms", "self-perceptive symptoms" and "general symptoms", which described 80% of the symptoms presented.

CONCLUSION

We evidenced the importance of identifying these symptoms clusters in order to improve strategies for clinical management in patients with colorectal cancer.

摘要

背景

结直肠癌是全球第三大常见癌症类型,结直肠癌患者生存率的提高意义重大。因此,为了进行恰当的临床管理,研究与疾病进展及治疗相关的症状变得很有必要。

目的

描述结直肠癌患者的临床和流行病学特征,并确定最常见的体征和症状模式。

方法

采用横断面研究,评估一家肿瘤专科医院收治的348例结直肠癌患者的症状患病率。我们应用了MSAS-BR量表,并通过主成分分析进行因子分析,对症状进行分组。

结果

患者以60岁及以上、已婚、白人、高中学历、肿瘤中度分化、疾病处于III/IV期、结肠癌且无远处转移的男性为主。最常见的症状是体重减轻(67.53%),最不常见的是口腔溃疡(2.01%)。确定的症状分组为“疲劳和精神症状”、“胃肠道症状”、“自我感知症状”和“一般症状”,这些分组描述了所呈现症状的80%。

结论

我们证明了识别这些症状集群对于改善结直肠癌患者临床管理策略的重要性。

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