Hepatic fibrosis: A convergent response to liver injury that is reversible.
作者信息
Wang Shuang, Friedman Scott L
机构信息
Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY.
Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY.
出版信息
J Hepatol. 2020 Jul;73(1):210-211. doi: 10.1016/j.jhep.2020.03.011. Epub 2020 May 8.
Abstract
摘要
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本文引用的文献
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Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution.鉴定阻止肝星状细胞激活并促进纤维化消退的谱系特异性转录因子。
Gastroenterology. 2020 May;158(6):1728-1744.e14. doi: 10.1053/j.gastro.2020.01.027. Epub 2020 Jan 23.
2
A Deactivation Factor of Fibrogenic Hepatic Stellate Cells Induces Regression of Liver Fibrosis in Mice.一种成纤维细胞激活因子诱导小鼠肝纤维化消退。
Hepatology. 2020 Apr;71(4):1437-1452. doi: 10.1002/hep.30965. Epub 2020 Mar 6.
3
Portal pressure and liver stiffness measurements in the prediction of fibrosis regression after sustained virological response in recurrent hepatitis C.门静脉压力和肝硬度测量在预测丙型肝炎复发患者持续病毒学应答后纤维化消退中的作用。
Hepatology. 2018 May;67(5):1683-1694. doi: 10.1002/hep.29557. Epub 2018 Mar 24.
4
Mechanisms of hepatic stellate cell activation.肝星状细胞激活的机制。
Nat Rev Gastroenterol Hepatol. 2017 Jul;14(7):397-411. doi: 10.1038/nrgastro.2017.38. Epub 2017 May 10.
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Hepatostat: Liver regeneration and normal liver tissue maintenance.肝实质：肝脏再生和维持正常肝组织。
Hepatology. 2017 Apr;65(4):1384-1392. doi: 10.1002/hep.28988. Epub 2017 Mar 6.
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The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer.癌症相关成纤维细胞和纤维化在肝癌中的作用
Annu Rev Pathol. 2017 Jan 24;12:153-186. doi: 10.1146/annurev-pathol-052016-100322. Epub 2016 Dec 5.
7
Liver sinusoidal endothelial cells and liver regeneration.肝窦内皮细胞与肝再生。
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Deactivation of hepatic stellate cells during liver fibrosis resolution in mice.在小鼠肝纤维化消退过程中肝星状细胞的失活。
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Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9448-53. doi: 10.1073/pnas.1201840109. Epub 2012 May 7.
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Gut. 2006 Aug;55(8):1174-82. doi: 10.1136/gut.2005.082701. Epub 2006 Jan 19.
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