Oh Suhyun, Kim Si-Ho, Baek Jin Yang, Huh Kyungmin, Cho Sun Young, Kang Cheol-In, Chung Doo Ryeon, Huh Hee Jae, Lee Nam Yong, Peck Kyong Ran
Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, Republic of Korea.
J Infect Chemother. 2020 Sep;26(9):995-998. doi: 10.1016/j.jiac.2020.04.002. Epub 2020 May 10.
A 37-year-old healthy man was admitted with fever, skin rash, migratory arthralgia, and headache without preceding urogenital symptoms. Sexual contact history and positive CSF culture for Neisseria gonorrhoeae using BacT/Alert blood culture bottles were diagnostic for gonococcal meningitis. Multilocus sequence typing of this isolate showed sequence type (ST) 7363, the most predominant ST among ceftriaxone-resistant strains. The isolate from this case remained susceptible to ceftriaxone although it was resistant to penicillin, tetracycline, and ciprofloxacin. With the high selective pressure of ceftriaxone for treatment of plasmid-mediated β-lactamase producing N. gonorrhoeae, resistance to ceftriaxone and molecular characteristics should be monitored.
一名37岁健康男性因发热、皮疹、游走性关节痛和头痛入院，无先前的泌尿生殖系统症状。性接触史以及使用BacT/Alert血培养瓶对淋病奈瑟菌进行的脑脊液培养阳性，诊断为淋菌性脑膜炎。该分离株的多位点序列分型显示序列类型（ST）7363，是耐头孢曲松菌株中最主要的序列类型。尽管该病例的分离株对青霉素、四环素和环丙沙星耐药，但对头孢曲松仍敏感。鉴于头孢曲松在治疗质粒介导的产β-内酰胺酶淋病奈瑟菌时存在高选择压力，应监测对头孢曲松的耐药性及分子特征。
