Knapp J S, Mesola V P, Neal S W, Wi T E, Tuazon C, Manalastas R, Perine P L, Whittington W L
Division of Sexually Transmitted Diseases Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Sex Transm Dis. 1997 Jan;24(1):2-7. doi: 10.1097/00007435-199701000-00002.
Failure of gonococcal infections to respond to 500 mg of ciprofloxacin or 400 mg of ofloxacin has been reported from Australia, the United Kingdom, and the United States. Recently, high rates of decreased susceptibility to the fluoroquinolones have been detected in penicillinase-producing Neisseria gonorrhoeae in the Republic of the Philippines.
To assess the diversity of antimicrobial-resistant gonococcal strains isolated from female sex workers in Manila and Cebu City in the Republic of the Philippines in 1994.
Isolates of N. gonorrhoeae isolated from 92 female sex workers in Manila (n = 28) and Cebu City (n = 64), respectively, were characterized by plasmid profile, auxotype/serovar class, and antimicrobial susceptibility profile.
Plasmid-mediated resistance to penicillin or tetracycline was identified in 79.3% (73/92) of the isolates: penicillinase-producing N. gonorrhoeae (65/92; 70.7%), tetracycline-resistant N. gonorrhoeae (6/92; 6.5%), and penicillinase-producing/tetracycline-resistant N. gonorrhoeae (1/92; 1.1%). A beta-lactamase plasmid of 3.9 megadaltons was discovered. Of 54.3% (50/92) of strains resistant to nalidixic acid, 84% (42/50) of strains had minimum inhibitory concentrations of > or = 0.125 microgram/ml ciprofloxacin; penicillinase-producing N. gonorrhoeae (possessing the 3.05-, 3.2-, 3.9-, and 4.4-megadalton beta-lactamase plasmids, respectively) accounted for 68% (34/50) of these strains.
In the Republic of the Philippines, gonococcal isolates resistant to penicillin or tetracycline accounted for 85.9% (79/92) of the isolates examined and included strains exhibiting resistance to fluoroquinolones. All gonococcal infections should be treated with antimicrobial therapies known to be active against all gonococcal strains to reduce the spread of strains exhibiting decreased susceptibilities to fluoroquinolones.
澳大利亚、英国和美国均有报告称，淋球菌感染对500毫克环丙沙星或400毫克氧氟沙星无反应。最近，在菲律宾共和国产青霉素酶的淋病奈瑟菌中检测到对氟喹诺酮类药物敏感性降低的高发生率。
评估1994年从菲律宾共和国马尼拉和宿务市的女性性工作者中分离出的耐抗菌药淋球菌菌株的多样性。
分别从马尼拉（n = 28）和宿务市（n = 64）的92名女性性工作者中分离出淋病奈瑟菌菌株，并通过质粒图谱、辅助型/血清型类别和抗菌药敏图谱进行特征分析。
在79.3%（73/92）的分离株中鉴定出质粒介导的对青霉素或四环素的耐药性：产青霉素酶的淋病奈瑟菌（65/92；70.7%）、耐四环素的淋病奈瑟菌（6/92；6.5%）以及产青霉素酶/耐四环素的淋病奈瑟菌（1/92；1.1%）。发现了一个3.9兆道尔顿的β-内酰胺酶质粒。在对萘啶酸耐药的54.3%（50/92）菌株中，84%（42/50）菌株的环丙沙星最低抑菌浓度≥0.125微克/毫升；产青霉素酶的淋病奈瑟菌（分别拥有3.05、3.2、3.9和4.4兆道尔顿的β-内酰胺酶质粒）占这些菌株的68%（34/50）。
在菲律宾共和国，对青霉素或四环素耐药的淋球菌分离株占所检测分离株的85.9%（79/92），且包括对氟喹诺酮类药物耐药的菌株。所有淋球菌感染均应用已知对所有淋球菌菌株有效的抗菌疗法进行治疗，以减少对氟喹诺酮类药物敏感性降低的菌株的传播。
