RNA 介导的 Polycomb 调控的多面性。
The many faces of Polycomb regulation by RNA.
机构信息
Developmental Epigenetics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
Developmental Epigenetics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
出版信息
Curr Opin Genet Dev. 2020 Apr;61:53-61. doi: 10.1016/j.gde.2020.02.023. Epub 2020 May 11.
Many intricate pathways contribute to the timely control of gene expression during development. Polycomb repressive complexes (PRC1 and PRC2) and long non-coding RNAs (lncRNAs) are players associated with gene repression in various developmental processes such as X chromosome inactivation (XCI) and genomic imprinting. Historically, lncRNAs were proposed to directly recruit PRC2. However, recent evidence suggests that promiscuous interactions between PRC2 and RNA fine-tune the function of the complex through a multiplicity of mechanisms. A PRC2-recruitment model was definitively overturned in the paradigm of XCI by Xist RNA, being replaced by a novel mechanism which puts PRC1 in the spotlight. This review focuses on these recent advances in understanding the interplay between RNA and Polycomb complexes for gene expression control.
许多复杂的途径有助于在发育过程中及时控制基因表达。多梳抑制复合物（PRC1 和 PRC2）和长非编码 RNA（lncRNA）是与各种发育过程中的基因抑制相关的参与者，如 X 染色体失活（XCI）和基因组印记。历史上，lncRNA 被提议直接招募 PRC2。然而，最近的证据表明，PRC2 和 RNA 之间的混杂相互作用通过多种机制微调了复合物的功能。在 XCI 的范例中，PRC2 招募模型被 Xist RNA 明确推翻，取而代之的是一种将 PRC1 置于聚光灯下的新机制。本综述重点介绍了这些关于 RNA 和多梳复合物在基因表达调控中相互作用的最新进展。
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