State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Nat Cell Biol. 2019 May;21(5):542-551. doi: 10.1038/s41556-019-0311-8. Epub 2019 May 2.
A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential, are transcribed from the mammalian genome. They are emerging as important regulators in gene expression networks by controlling nuclear architecture and transcription in the nucleus and by modulating mRNA stability, translation and post-translational modifications in the cytoplasm. In this Review, we highlight recent progress in cellular functions of lncRNAs at the molecular level in mammalian cells.
大量的长非编码 RNA（lncRNA）缺乏蛋白编码潜能，它们从哺乳动物基因组中转录而来。它们通过控制核内的核结构和转录，并通过调节细胞质中 mRNA 的稳定性、翻译和翻译后修饰，在基因表达网络中作为重要的调控因子而出现。在这篇综述中，我们强调了哺乳动物细胞中 lncRNA 的分子水平上的细胞功能的最新进展。
