Rosenfeld E, Ponsold W, Hoffmann P
Martin-Luther-Universität, Halle-Wittenberg, Institut für Industrietoxikologie, Bereich Medizin, DDR.
Biomed Biochim Acta. 1988;47(8):761-6.
The incisor of the rat is a sensitive biological indicator which records nutritive and hormonal disorders as well as toxic influences. The present investigation was aimed to provide information whether or not the manifestation of cyclophosphamide-caused hypoplasias could be altered by an induction (phenobarbital) or inhibition (carbon tetrachloride) of the liver biotransformation capacity. Cyclophosphamide (15 or 30 mg/kg) was injected intraperitoneally. Pretreatment of the rat with phenobarbital produced an increase (35%) of the malformation, whereas carbon tetrachloride led to a dose dependent decrease (30 or 50%). Our investigations suggest that the cyclophosphamide induced defect of the incisor is due to an alteration of the metabolic liver function.
大鼠的门牙是一种敏感的生物学指标，可记录营养和激素紊乱以及毒性影响。本研究旨在提供信息，即环磷酰胺引起的发育不全的表现是否会因肝脏生物转化能力的诱导（苯巴比妥）或抑制（四氯化碳）而改变。腹腔注射环磷酰胺（15或30mg/kg）。用苯巴比妥预处理大鼠会使畸形增加（35%），而四氯化碳则导致剂量依赖性降低（30%或50%）。我们的研究表明，环磷酰胺诱导的门牙缺陷是由于肝脏代谢功能的改变。
