Yan J J, Fan H Q, Yang L
Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
Zhonghua Gan Zang Bing Za Zhi. 2020 Apr 20;28(4):361-364. doi: 10.3760/cma.j.cn501113-20190308-00074.
With the research advances on bile acid, it has gradually been discovered and confirmed that high levels of bile acids can cause various types of arrhythmias, such as sinus bradycardia, atrial fibrillation (AF), atrioventricular block and even occurrence of cardiac arrest in severe cases. In addition, it has also been found that fetuses are more susceptible to bile acid-induced arrhythmias than adults. It has been recognized that bile acids can cause arrhythmias through a variety of mechanisms, such as the effect of bile acids on ions and ion channels, receptor-mediated, vagal-mediated, and other pathways. Ursodeoxycholic acid (UDCA) is currently found to have protective effect on the heart and has an antiarrhythmic effect. This article mainly reviews the function and mechanism of bile acid in arrhythmia.
随着对胆汁酸研究的进展，人们逐渐发现并证实，高水平的胆汁酸可导致各种类型的心律失常，如窦性心动过缓、心房颤动（房颤）、房室传导阻滞，严重时甚至会发生心脏骤停。此外，还发现胎儿比成人更容易受到胆汁酸诱导的心律失常的影响。人们已经认识到，胆汁酸可通过多种机制导致心律失常，如胆汁酸对离子和离子通道的作用、受体介导、迷走神经介导等途径。目前发现熊去氧胆酸（UDCA）对心脏具有保护作用并有抗心律失常作用。本文主要综述胆汁酸在心律失常中的作用及机制。
