Department of Neurology, Harvard Medical School , Boston, MA, USA.
Child Neuropsychol. 2020 Jul;26(5):577-596. doi: 10.1080/09297049.2020.1763938. Epub 2020 May 13.
Children have shown more physical resilience to COVID-19 than adults, but there is a cohort of vulnerable infants and young children who may experience disease burden, both in the acute phase and chronically. Children may have had early undocumented exposure to COVID-19. Even when the risk of exposure was known, developmental variables may have made the avoidance of physical proximity difficult for children. Preliminary hypotheses concerning neurotropic factors have been documented by researchers. Children with COVID-19 and comorbid physical or mental disorders may be vulnerable to exacerbations of neurotropic factors and comorbidities, the neural impact of which has been documented for other coronaviruses. Researchers are investigating COVID-19 symptom descriptions, neurotropic mechanisms at the genomic and transcriptomatic levels, neurological manifestations, and the impact of comorbid health complications. Neuropsychologists need information concerning the likely impact of COVID-19 on children. With a view toward that goal, this article provides recommendations for some initial updates in neuropsychology practice.
儿童对 COVID-19 的身体抵抗力强于成人，但有一群脆弱的婴儿和幼儿可能会在急性期和慢性期都遭受疾病负担。儿童可能在早期就曾未被记录地接触过 COVID-19。即使知道接触的风险，发育变量可能使儿童难以避免身体接触。研究人员已经记录了关于神经营养因素的初步假设。患有 COVID-19 及伴发的身体或精神疾病的儿童可能容易受到神经营养因素和伴发疾病的恶化影响，其他冠状病毒已记录了这些因素对神经的影响。研究人员正在研究 COVID-19 的症状描述、基因组和转录组水平的神经营养机制、神经表现以及伴发健康并发症的影响。神经心理学家需要了解 COVID-19 对儿童可能产生的影响的信息。为此，本文为神经心理学实践中的一些初步更新提供了建议。
