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新冠疫情下的医疗先驱:识别新冠病毒引发的神经功能障碍

Heralding Healthcare Professionals: Recognition of Neurological Deficits in COVID-19.

机构信息

Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan.

Mount Auburn Hospital, Boston Urogynecology Associates, Cambridge, Massachusetts 02138, United States.

出版信息

ACS Chem Neurosci. 2020 Jun 17;11(12):1701-1703. doi: 10.1021/acschemneuro.0c00286. Epub 2020 May 29.

Abstract

The 2019 novel coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a zoonotic disease that is dominated by pulmonary symptoms. However, recent reports of isolation of the virus from cerebrospinal fluid (CSF) coupled with radiological evidence of zones of necrosis in the brain, have elucidated the neurotropic potential of SARS-CoV-2. The acute respiratory failure seen in patients with COVID-19 is alarming and could be due to the effects of SARS-CoV-2 on the central respiratory regulatory centers in the brainstem. Appropriate interventions can be implemented to prevent severe outcomes of neurological invasion by SARS-CoV-2 to reduce the morbidity and mortality of patients with COVID-19. It is of paramount importance that the scientific community alerts the healthcare professionals of the pieces of evidence that can herald them on the covert neurological deficits in progress in COVID-19.

摘要

由严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)引起的 2019 年新型冠状病毒病(COVID-19)是一种以肺部症状为主的人畜共患病。然而,最近有报道从脑脊液(CSF)中分离出病毒,结合大脑坏死区域的影像学证据,阐明了 SARS-CoV-2 的神经嗜性。COVID-19 患者出现的急性呼吸衰竭令人警惕,可能是由于 SARS-CoV-2 对脑干中央呼吸调节中心的影响。可以实施适当的干预措施,以防止 SARS-CoV-2 对神经系统的严重侵犯,从而降低 COVID-19 患者的发病率和死亡率。至关重要的是,科学界提醒医疗保健专业人员注意可能预示 COVID-19 中隐匿性神经缺陷进展的证据。

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