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双切迹的力学机制:加速度假说。

Mechanics of the dicrotic notch: An acceleration hypothesis.

机构信息

Bioengineering, Imperial College, London, UK.

Aswan Heart Centre, Aswan, Egypt.

出版信息

Proc Inst Mech Eng H. 2020 Nov;234(11):1253-1259. doi: 10.1177/0954411920921628. Epub 2020 May 13.

Abstract

The dicrotic notch is a prominent and distinctive feature of the pressure waveform in the central arteries. It is universally used to demarcate the end of systole and the beginning of diastole in these arteries. Despite its importance clinically, no physical mechanism for the formation of the dicrotic notch has been demonstrated convincingly. We first explore a mechanism based on the reflection of a backward wavefront from the aortic valve at the time of closure. This hypothesis is rejected on the basis of experimental evidence from measurements made in dogs. A new hypothesis is presented involving the acceleration of the aortic valve apparatus at the time of valve closure. This hypothesis is supported by new calculations of the acceleration of the aortic valve apparatus during the cardiac cycle based on computed tomography scans in man.

摘要

双峰切迹是中心动脉压力波形的一个显著而独特的特征。它被广泛用于标记这些动脉中收缩期的结束和舒张期的开始。尽管它在临床上很重要,但尚未令人信服地证明双峰切迹形成的物理机制。我们首先探讨了一种基于在瓣关闭时主动脉瓣后向波前反射的机制。这一假说基于在狗身上进行的测量的实验证据被否定了。提出了一个新的假说,涉及瓣关闭时主动脉瓣装置的加速。这一假说得到了基于人体计算机断层扫描的心脏周期中主动脉瓣装置加速度的新计算的支持。

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