Department of Neurological Surgery, Tama Nagayama Hospital, Nippon Medical School.
Department of Neurological Surgery, Chiba Hokusoh Hospital, Nippon Medical School.
Neurol Med Chir (Tokyo). 2020 Jun 15;60(6):293-298. doi: 10.2176/nmc.oa.2019-0193. Epub 2020 May 14.
Carotid artery stenosis is elicited by atherosclerosis and is the main cause of cerebral thrombosis. Flow-mediated endothelial vasodilation (FMD) can be measured noninvasively to assess vascular endothelial function related to atherosclerosis. The pulse wave velocity (PWV) is used to evaluate the vascular media involved in atherosclerosis. We investigated the relationship between these measurements in 75 consecutive patients with atherosclerotic cerebral thrombosis. They were assigned to three equal groups based on the severity of carotid artery stenosis on ultrasonograms. Group 1 had no stenosis, group 2 manifested moderate stenosis (<60%), and group 3 presented with severe stenosis (≥60%). We compared the FMD and PWV among the three groups. The PWV was significantly lower in group 1 than the other two groups. The FMD was significantly lower in group 3; it was significantly lower in group 2 than group 1. There was an inverse correlation between the FMD and the severity of carotid artery stenosis. Our findings show that for assessing the severity of carotid artery stenosis, the FMD is more useful than the PWV.
颈动脉狭窄是由动脉粥样硬化引起的，是脑血栓形成的主要原因。血流介导的内皮血管舒张（FMD）可以通过非侵入性测量来评估与动脉粥样硬化相关的血管内皮功能。脉搏波速度（PWV）用于评估动脉粥样硬化涉及的血管中层。我们在 75 例连续的动脉粥样硬化性脑血栓形成患者中研究了这些测量值之间的关系。根据超声检查颈动脉狭窄的严重程度，他们被分为三组。第 1 组无狭窄，第 2 组表现为中度狭窄（<60%），第 3 组表现为严重狭窄（≥60%）。我们比较了三组之间的 FMD 和 PWV。第 1 组的 PWV 明显低于其他两组。第 3 组的 FMD 明显较低；与第 1 组相比，第 2 组的 FMD 明显较低。FMD 与颈动脉狭窄的严重程度呈负相关。我们的研究结果表明，在评估颈动脉狭窄的严重程度方面，FMD 比 PWV 更有用。
