Wang Xiao-Jun, Qian Xi-Wen, Zhang Xu, Han Li, Zheng Yu-Qi, Wu Tao, Qin Guo-You, Ye Zhi-Bin, Xiao Jing
Department of Traditional Chinese Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.
Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.
Chin Med J (Engl). 2020 Jun 20;133(12):1409-1414. doi: 10.1097/CM9.0000000000000840.
The relationship of uric acid (UA) with the thyroid function among healthy individuals remains unclear. We aimed to examine the relationship between UA contents and thyroid hormone levels in healthy Chinese individuals.
This was a cross-sectional study of 1186 Chinese adults (736 men and 450 women) who underwent a health check-up at the Huadong Hospital Affiliated to Fudan University (Shanghai, China) between January 1, 2010 and July 31, 2018. Clinical and thyroid hormone levels were compared in different UA groups (in male and menopause women groups, MG1: UA < 5 mg/dL; MG2: 5 mg/dL ≤ UA< 7 mg/dL; and MG3: UA ≥ 7 mg/dL; in female groups, FG1 to FG3 represent the UA levels of <4 mg/dL, 4 mg/dL ≤ UA< 6 mg/dL, and ≥6 mg/dL, respectively). In addition, natural cubic spline regression, together with Pearson correlation analysis, was performed in investigating the correlation of UA with thyroid hormones.
After adjusting for confounding factors, low levels of UA (for males, UA < 5.30 mg/dL; for females, UA < 4.05 mg/dL) were negatively correlated with free triiodothyronine (FT3) both in men and women. UA levels between 4.83 and 6.06 mg/dL may act to protect FT3 in women, while UA levels between 6.39 and 7.09 mg/dL may protect FT3 in men. FT3 levels of low-range UA group reduced compared with mid-range UA and the high-range UA groups in both men and women.
Our results provide epidemiologic evidence to support the negative correlation between low UA contents and FT3 in the Chinese Han population, suggesting that the reduced UA contents may serve as the risk factor to predict poor thyroid function in Chinese individuals.
健康个体中尿酸（UA）与甲状腺功能的关系尚不清楚。我们旨在研究健康中国人群中尿酸含量与甲状腺激素水平之间的关系。
这是一项横断面研究，研究对象为2010年1月1日至2018年7月31日期间在复旦大学附属华东医院（中国上海）进行健康体检的1186名中国成年人（736名男性和450名女性）。比较不同尿酸组（男性和绝经后女性组中，MG1：尿酸<5mg/dL；MG2：5mg/dL≤尿酸<7mg/dL；MG3：尿酸≥7mg/dL；女性组中，FG1至FG3分别代表尿酸水平<4mg/dL、4mg/dL≤尿酸<6mg/dL和≥6mg/dL）的临床和甲状腺激素水平。此外，采用自然立方样条回归和Pearson相关分析来研究尿酸与甲状腺激素的相关性。
在调整混杂因素后，低尿酸水平（男性尿酸<5.30mg/dL；女性尿酸<4.05mg/dL）在男性和女性中均与游离三碘甲状腺原氨酸（FT3）呈负相关。尿酸水平在4.83至6.06mg/dL之间可能对女性的FT3有保护作用，而尿酸水平在6.39至7.09mg/dL之间可能对男性的FT3有保护作用。男性和女性低尿酸组的FT3水平均低于中尿酸组和高尿酸组。
我们的结果提供了流行病学证据，支持中国汉族人群中低尿酸含量与FT3之间的负相关关系，表明尿酸含量降低可能是预测中国个体甲状腺功能不良的危险因素。
