Horowitz-Kraus Tzipi, DiCesare Christopher, Kiefer Adam W
Educational Neuroimaging Center, Faculty of Education in Science and Technology and Faculty of Biomedical Engineering, Technion.
Department of Pediatrics, Reading and Literacy Discovery Center.
Mind Brain Educ. 2018 Mar;12(1):49-60. doi: 10.1111/mbe.12168. Epub 2018 Jun 19.
Dyslexia, or reading difficulty (RD), is characterized by slow, inaccurate reading and accompanied by deficit in executive functions (EF) and altered functional connectivity (FC) in the related networks (i.e., cingulo-opercular). Individuals with RD also present with altered oculomotor gaze patterns that include longer fixation times. The researchers examined the relationship between fixation times and FC of neural circuits related to EF during rest in children with RD and typical readers. Nineteen children participated in a 10-min resting-state scan. FC analysis was performed with the anterior cingulate cortex (ACC), related to cognitive control, chosen as a seed. Fixation time during word reading was used as a covariate of interest. Results demonstrated that FC between the ACC and the left inferior frontal cortex pars triangularis and left inferior prefrontal cortex during rest were negatively correlated with fixation times during word reading. These exploratory results support the critical role for the cingulo-opercular network, which is related to cognitive control, in the reading process, and likely also in reading impairment.
阅读障碍，即阅读困难（RD），其特征是阅读速度慢、不准确，并伴有执行功能（EF）缺陷以及相关网络（即扣带回-脑岛网络）中功能连接（FC）改变。患有阅读障碍的个体还表现出眼动注视模式改变，包括更长的注视时间。研究人员研究了阅读障碍儿童和正常阅读儿童在静息状态下注视时间与与执行功能相关的神经回路功能连接之间的关系。19名儿童参与了一次10分钟的静息态扫描。以与认知控制相关的前扣带回皮质（ACC）作为种子进行功能连接分析。单词阅读时的注视时间用作感兴趣的协变量。结果表明，静息状态下ACC与左侧额下回三角部和左侧前额叶皮质之间的功能连接与单词阅读时的注视时间呈负相关。这些探索性结果支持了与认知控制相关的扣带回-脑岛网络在阅读过程中以及可能在阅读障碍中所起的关键作用。
