胆固醇官能化的脂肪族取代八元环状碳酸酯。
Cholesterol functionalized aliphatic -substituted 8-membered cyclic carbonate.
作者信息
Venkataraman Shrinivas, Mineart Kenneth P, Prabhu Vivek M, Hedrick James L, Yang Yi Yan
机构信息
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.
Material Measurement Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, Maryland 20899, USA.
出版信息
Polym Chem. 2018 May 14;9(18):2434-2437. doi: 10.1039/c8py00406d. Epub 2018 Apr 10.
Abstract
Straightforward synthesis of cholesterol functionalized aliphatic -substituted 8-membered cyclic carbonate (Chol-8m) monomer is reported. Well-defined poly(ethylene glycol) (PEG) diblock copolymers were readily accessed via organo catalytic ring opening polymerization. These polymers show promise as building blocks for self-assembled nanostructures and steric stabilizers for liposomes.
摘要
报道了胆固醇官能化脂肪族取代的八元环状碳酸酯（Chol-8m）单体的直接合成方法。通过有机催化开环聚合可轻松制备出结构明确的聚乙二醇（PEG）二嵌段共聚物。这些聚合物有望作为自组装纳米结构的构建单元和脂质体的空间稳定剂。
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