Department of Cerebral Surgery, The First Affiliated Hospital of Peking University, Beijing, China.
Genex Health Co, Ltd, Beijing, China.
Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820922587. doi: 10.1177/1533033820922587.
Lung cancer remains one of the leading causes of cancer deaths around the world. Previous studies have shown that microRNAs have pivotal functions in tumorigenesis including lung cancer. It is reported that microRNA-195-5p acts as a tumor suppressor role in human cancers. However, the function and molecular mechanism of microRNA-195-5p in lung cancer progression is still unclear. In the present study, the results showed that the expression of microRNA-195-5p was downregulated both in lung cancer tissues and in lung cancer cell lines. Enhanced expression of microRNA-195-5p inhibited cell proliferation, migration, and invasion in lung cancer cells. Furthermore, Forkhead box k1 was identified as the direct target of microRNA-195-5p. Forkhead box k1 overexpression could restore the repressed cell proliferation and metastasis caused by microRNA-195-5p overexpression. Our results demonstrated that a functional mechanism of microRNA-195-5p in regulating lung cancer. It indicates that microRNA-195-5p may regulate lung cancer growth and metastasis through the regulation of Forkhead box k1, highlighting the potential application for the treatment of lung cancer in the future.
肺癌仍然是全球癌症死亡的主要原因之一。先前的研究表明，microRNAs 在肿瘤发生中具有关键作用，包括肺癌。据报道，microRNA-195-5p 在人类癌症中发挥肿瘤抑制作用。然而，microRNA-195-5p 在肺癌进展中的功能和分子机制尚不清楚。在本研究中，结果表明，microRNA-195-5p 的表达在肺癌组织和肺癌细胞系中均下调。microRNA-195-5p 的过表达抑制了肺癌细胞的增殖、迁移和侵袭。此外，叉头框蛋白 K1 被鉴定为 microRNA-195-5p 的直接靶标。叉头框蛋白 K1 的过表达可以恢复 microRNA-195-5p 过表达引起的增殖和转移抑制。我们的结果表明，microRNA-195-5p 在调节肺癌中的功能机制。这表明，microRNA-195-5p 可能通过调节叉头框蛋白 K1 来调节肺癌的生长和转移，这突显了其在未来治疗肺癌方面的潜在应用。
