Department of Clinical Laboratory, Division of Maolin, The 967th Hospital of Joint Logistic Support Force of PLA, Dalian 116041, China.
Department of Clinical Laboratory, Division of Shengli, The 967th Hospital of Joint Logistic Support Force of PLA, Dalian 116011, China.
J Asian Nat Prod Res. 2021 Jul;23(7):652-659. doi: 10.1080/10286020.2020.1758931. Epub 2020 May 14.
Three previously undescribed -abietane-type diterpenoids, designated as 11-hydroxy-14-oxo-17-al--abieta-8(9),13(15)-dien-16,12-olide (), 11,17-dihydroxy-12-methoxy--abieta-8(14),13(15)-dien-16,12-olide (), and 14-hydroxy-17-al--abieta-7(8),11(12),13(15)-trien-16,12-olide (), were isolated from 95% ethanol extract of the roots of . The structures of the new compounds were elucidated by spectroscopic analysis (NMR, IR, UV, and MS). The isolated diterpenoids were tested for antimicrobial potentials against 6 pathogenic microorganisms. As a result, compounds - exhibited some antimicrobial activity against the tested Gram positive bacteria with minimum inhibitory concentration values less than 60 μg/ml.[Formula: see text].
从 的根的 95%乙醇提取物中分离得到三种以前未描述的 -贝壳杉烷型二萜类化合物，分别命名为 11-羟基-14-氧代-17- -贝壳杉-8(9),13(15)-二烯-16,12-内酯 (), 11,17-二羟基-12-甲氧基- -贝壳杉-8(14),13(15)-二烯-16,12-内酯 ()和 14-羟基-17- -贝壳杉-7(8),11(12),13(15)-三烯-16,12-内酯 ()。新化合物的结构通过光谱分析（NMR、IR、UV 和 MS）阐明。对分离得到的二萜类化合物进行了抗微生物潜力测试，以评估它们对 6 种致病性微生物的抑制活性。结果表明，化合物 - 对测试的革兰氏阳性菌具有一定的抗菌活性，最小抑菌浓度值小于 60μg/ml。[化学式：见正文]。
