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从 中分离得到的具有抗增殖作用的枞烷二萜。

Antiproliferative -abietane diterpenoids from .

机构信息

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.

出版信息

Nat Prod Res. 2023 Nov-Dec;37(24):4081-4088. doi: 10.1080/14786419.2023.2169686. Epub 2023 Jan 20.

Abstract

Euphorfinoids M and N ( and ), two previously undescribed -abietane diterpenoids, together with seven known analogues (-), were isolated from the roots of wild . Their structures were elucidated by spectroscopic analysis, including extensive NMR, HR-ESIMS, ECD, and comparison with structurally related known analogues. Bioassays against proliferative effects of HeLa cell line showed that compound was the most active with IC 3.62 ± 0.31 μM.

摘要

Euphorfinoids M 和 N(以及),两种以前未描述的 -abietane 二萜类化合物,与七种已知类似物(-)一起从野生的根部分离出来。通过包括广泛的 NMR、HR-ESIMS、ECD 以及与结构相关的已知类似物的比较在内的光谱分析阐明了它们的结构。对 HeLa 细胞系增殖作用的生物测定表明,化合物是最活跃的,IC 为 3.62 ± 0.31 μM。

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