合成香芹酚和百里香酚的磺酸衍生物作为抗卵菌剂。
Synthesis of sulfonate derivatives of carvacrol and thymol as anti-oomycetes agents.
机构信息
Laboratory of Pesticidal Design and Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
出版信息
J Asian Nat Prod Res. 2021 Jul;23(7):692-702. doi: 10.1080/10286020.2020.1758675. Epub 2020 May 14.
Two series of sulfonate derivatives of carvacrol and thymol were synthesized and screened for their anti-oomycete activity against , respectively. Among all of 32 derivatives, five compounds , , , and exhibited more potent anti-oomycete activity against with EC values of 66.66, 62.94, 68.65, 61.24, and 52.91 mg/L, respectively. This suggested that introduction of different substitutions at the hydroxyl position of / could have remarkable effect on anti-oomycete activity. Overall, when R = isopropyl and R = methyl, the anti-oomycete activities of the compounds were higher than that of the corresponding compounds of R = methyl and R = isopropyl.[Formula: see text].
合成了香芹酚和麝香草酚的两个系列磺酸酯衍生物，并分别对其抗卵菌活性进行了筛选。在所合成的 32 个衍生物中，有 5 个化合物,,, 和 对 的 EC 值分别为 66.66、62.94、68.65、61.24 和 52.91mg/L，表现出更强的抗卵菌活性。这表明在 / 的羟基位置引入不同取代基对其抗卵菌活性有显著影响。总体而言，当 R = 异丙基且 R = 甲基时，化合物的抗卵菌活性高于 R = 甲基且 R = 异丙基的相应化合物。[化学式：见正文]。
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