Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
Hunan Children's Hospital, Medical Record Statistics and Library Management Office, Changsha, China.
Genet Test Mol Biomarkers. 2020 Jun;24(6):364-369. doi: 10.1089/gtmb.2019.0275. Epub 2020 May 14.
To explore the association of the gene polymorphisms (rs4680, rs737866, and rs933271) with the response to methadone maintenance treatment (MMT) among Chinese opioid-dependent patients. A total of 820 patients who were receiving MMT from Chinese clinics were recruited. Questionnaires were used to collect patient information, including sociodemographics, history of drug use, and stable methadone dosages. Three polymorphisms of , rs4680, rs737866, and rs933271, were selected and genotyped using the Sequenom MassARRAY platform. After adjusting for related factors including age, marital status, and methadone dosage, the genotype TC at rs933271 was demonstrated as the dominant difference between the MMT responsive group and nonresponsive group ( = 0.02, odds ratios [OR]: 1.57). In the dominant model of inheritance, the individuals carrying the TC or CC genotypes at rs933271 were more likely to respond to MMT than patients with the genotype TT ( = 0.02, OR: 1.53). No significant associations were observed between any of the allelic or genotypic variants of the rs4680 and rs737866 loci, and the response to MMT in this Chinese population. Patients with the haplotype A-T-A (rs737866-rs933271-rs4680) were more frequent in the nonresponsive group than in the responsive group ( < 0.05). genetic variability is associated with the response to MMT.
探讨 基因多态性（rs4680、rs737866 和 rs933271）与中国阿片类依赖患者对美沙酮维持治疗（MMT）反应的相关性。共招募了 820 名正在中国诊所接受 MMT 的患者。问卷用于收集患者信息，包括社会人口统计学、吸毒史和稳定的美沙酮剂量。选择了三个 基因多态性 rs4680、rs737866 和 rs933271，并使用 Sequenom MassARRAY 平台进行基因分型。在调整年龄、婚姻状况和美沙酮剂量等相关因素后，rs933271 的 TC 基因型被证明是 MMT 反应组和非反应组之间的显性差异（=0.02，比值比 [OR]：1.57）。在 rs933271 的显性遗传模式中，携带 TC 或 CC 基因型的个体比 TT 基因型的个体更有可能对 MMT 产生反应（=0.02，OR：1.53）。在中国人群中，未观察到 rs4680 和 rs737866 位点的任何等位基因或基因型变异与 MMT 反应之间存在显著关联。rs737866-rs933271-rs4680 单倍型 A-T-A 的患者在非反应组中比在反应组中更为常见（<0.05）。基因多态性与 MMT 反应有关。
