Heimsoth V, Loew D, Schuster O
Chefarzt der Inneren Abtlg., Ostsee-Klinik, Damp, FRG.
Eur J Drug Metab Pharmacokinet. 1988 Jul-Sep;13(3):161-4. doi: 10.1007/BF03189935.
In a randomized cross-over study the saluretic effect of furosemide-retard was compared with the combination of furosemide-retard/triamterene in 10 healthy male volunteers. The combination led to a significantly stronger excretion of sodium and a significantly lower excretion of potassium than furosemide-retard. The interaction of the saluretic with the antikaliuretic was even more distinctly expressed regarding sodium related quotients. The combination furosemide-retard/triamterene differs significantly from furosemide-retard in the main considering Na+/Cl-, Na+/K+ and Na+/Mg2+ quotients. The concentration time curves for furosemide and OH-TA-sulphate in the plasma are nearly similar. Maximal plasma levels for furosemide are reached after 3.9h and for OH-TA-sulphate after 2.2h. The 'apparent' elimination half-life time for furosemide is 2.1h and the elimination half-life time for OH-TA-sulphate is 2.0h.
在一项随机交叉研究中，对10名健康男性志愿者比较了缓释速尿与缓释速尿/氨苯蝶啶联合用药的利钠利尿作用。与缓释速尿相比，联合用药导致钠排泄显著增强，钾排泄显著降低。就钠相关比值而言，利钠利尿剂与抗钾利尿剂的相互作用表现得更为明显。缓释速尿/氨苯蝶啶联合用药在主要考虑Na+/Cl-、Na+/K+和Na+/Mg2+比值时与缓释速尿有显著差异。血浆中速尿和OH-TA-硫酸盐的浓度-时间曲线几乎相似。速尿在3.9小时后达到最大血浆水平，OH-TA-硫酸盐在2.2小时后达到最大血浆水平。速尿的“表观”消除半衰期为2.1小时，OH-TA-硫酸盐的消除半衰期为2.0小时。
