van Meyel J J, Tan Y, Smits P, Russel F G, van Ginneken C A, Gribnau F W
Department of Pharmacology and Clinical Pharmacology, University of Nijmegen, The Netherlands.
Eur J Clin Pharmacol. 1990;39(6):595-7. doi: 10.1007/BF00316104.
The absorption and diuretic effect of furosemide 40 mg alone (F), and of the free (F + T) and the fixed (FT) combinations of furosemide 40 mg and triamterene 50 mg have been compared in 12 healthy young men. A slight reduction in the area under the concentration-time curve (AUC) of plasma furosemide was found for the fixed combination (AUC480) F2.58 micrograms.h.ml-1; F + T 2.46 micrograms.h.ml-1; FT 1.97 micrograms.h.ml-1. There was a significant reduction in the AUC480 of plasma triamterene (F + T 204.9 micrograms.h.l-1; FT 130.2 micrograms.h.l-1). Sodium excretion after F + T and FT was more pronounced than after F (F + T 302 mmol; FT 311 mmol; F259 mmol). When compared to F alone, there was a reduction in the 24-hour potassium excretion after F + T as well as after FT (F 121 mmol; F + T 104 mmol; FT 107 mmol). It is concluded that the absorption of triamterene was significantly reduced after ingestion of the fixed combination tablet. However, in healthy male adults this had no influence on its natriuretic and potassium-sparing effect as compared to the free combination.
在12名健康年轻男性中比较了单独使用40毫克呋塞米（F）、40毫克呋塞米与50毫克氨苯蝶啶的游离组合（F + T）和固定组合（FT）的吸收及利尿作用。固定组合使血浆呋塞米浓度-时间曲线下面积（AUC）略有降低（AUC480）：F为2.58微克·小时·毫升⁻¹；F + T为2.46微克·小时·毫升⁻¹；FT为1.97微克·小时·毫升⁻¹。血浆氨苯蝶啶的AUC480有显著降低（F + T为204.9微克·小时·升⁻¹；FT为130.2微克·小时·升⁻¹）。F + T和FT后的钠排泄比F后更显著（F + T为302毫摩尔；FT为311毫摩尔；F为259毫摩尔）。与单独使用F相比，F + T以及FT后24小时钾排泄减少（F为121毫摩尔；F + T为104毫摩尔；FT为107毫摩尔）。结论是，服用固定组合片剂后氨苯蝶啶的吸收显著降低。然而，在健康成年男性中，与游离组合相比，这对其利钠和保钾作用没有影响。
