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N1-葡萄糖苷作为磺胺嘧啶、磺胺甲嘧啶和磺胺甲恶唑的尿液代谢产物。

N1-glucosides as urinary metabolites of sulphadimidine, sulphamerazine and sulphamethoxazole.

作者信息

Ahmad B, Powell J W

机构信息

Department of Pharmaceutical Chemistry, School of Pharmacy, London, U.K.

出版信息

Eur J Drug Metab Pharmacokinet. 1988 Jul-Sep;13(3):177-83. doi: 10.1007/BF03189937.

DOI:10.1007/BF03189937
PMID:3240763
Abstract

The synthesis and characterisation of the N1-beta-D-glucosides of the three title sulphonamides are described, and these conjugates are shown, by means of HPLC and MS, to be minor urinary metabolites of these drugs.

摘要

描述了三种标题磺酰胺的N1-β-D-葡糖苷的合成与表征，并且通过高效液相色谱法和质谱法表明这些缀合物是这些药物的次要尿液代谢物。

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N1-glucosides as urinary metabolites of sulphadimidine, sulphamerazine and sulphamethoxazole.N1-葡萄糖苷作为磺胺嘧啶、磺胺甲嘧啶和磺胺甲恶唑的尿液代谢产物。
Eur J Drug Metab Pharmacokinet. 1988 Jul-Sep;13(3):177-83. doi: 10.1007/BF03189937.
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引用本文的文献

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Pharm Weekbl Sci. 1990 Apr 27;12(2):51-9. doi: 10.1007/BF01970146.

本文引用的文献

1
Simultaneous determination of trimethoprim, sulphamethoxazole and N4-acetylsulphamethoxazole in serum and urine by high-performance liquid chromatography.高效液相色谱法同时测定血清和尿液中的甲氧苄啶、磺胺甲恶唑及N4-乙酰磺胺甲恶唑
J Chromatogr. 1981 Apr 10;223(1):139-45. doi: 10.1016/s0378-4347(00)80076-6.
2
The structure of the glucuronide of sulphadimethoxine formed in man.人身体内形成的磺胺二甲氧嘧啶葡糖醛酸化物的结构。
Biochem J. 1965 Sep;96(3):829-36. doi: 10.1042/bj0960829.
3
The actylation of sulamethazine and sulfamethoxypyridazine by human subjects.
人对磺胺二甲嘧啶和磺胺甲氧哒嗪的乙酰化作用。
Clin Pharmacol Ther. 1968 Jan-Feb;9(1):80-8. doi: 10.1002/cpt19689180.
4
The metabolism of four sulphonamides in cows.四种磺胺类药物在奶牛体内的代谢
Biochem J. 1973 Dec;136(4):1039-45. doi: 10.1042/bj1361039.
5
Determination of pharmacokinetic parameters for rapid and slow acetylators of sulphadimidine.磺胺二甲嘧啶快速和慢速乙酰化者的药代动力学参数测定
J Pharm Pharmacol. 1972 May;24(5):357-60. doi: 10.1111/j.2042-7158.1972.tb09007.x.
6
Determination of pharmacokinetic parameters for urinary excretion of sulphafurazole under normal and controlled alkaline urine conditions.正常及可控碱性尿液条件下磺胺异噁唑尿排泄的药代动力学参数测定
J Pharm Pharmacol. 1970 Mar;22(3):224-6. doi: 10.1111/j.2042-7158.1970.tb08502.x.
7
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J Pharm Sci. 1976 Nov;65(11):1606-8. doi: 10.1002/jps.2600651111.
8
Metabolic fate of phenobarbital in man. N-Glucoside formation.
Drug Metab Dispos. 1979 Sep-Oct;7(5):315-8.
9
Metabolism and disposition by the rat of 35S-sulfadiazine alone and in the presence of trimethoprim.大鼠对单独的35S-磺胺嘧啶以及在甲氧苄啶存在情况下的代谢与处置。
Drug Metab Dispos. 1979 Mar-Apr;7(2):94-9.