Rodríguez-Mortera Reyna, Caccavello Russell, Garay-Sevilla Ma Eugenia, Gugliucci Alejandro
Department of Medical Science, University of Guanajuato, Mexico; Glycation, Oxidation and Disease Laboratory, Dept. of Research, College of Osteopathic Medicine, Touro University California, United States.
Glycation, Oxidation and Disease Laboratory, Dept. of Research, College of Osteopathic Medicine, Touro University California, United States.
Clin Chim Acta. 2020 Sep;508:61-68. doi: 10.1016/j.cca.2020.05.014. Epub 2020 May 11.
We hypothesized that adolescents with obesity have higher remnant B48 concentrations associated with lipoprotein lipase dysregulation.
Cross-sectional study of 32 adolescents with obesity and 27 control subjects.
As compared to lean controls, obese participants showed 35% higher concentrations of apoB48: 3.60 (2.93-4.30) vs 2.65 (1.64-3.68) ng/ml; 28% of apoC-III: (72.7 (58.6-89.7) vs 56.9 (44.8-79.8 ug/ml and 17% ANGPTL 3: (72.2 ± 20.2 vs 61.2 ± 19.2 ng/ml). This was accompanied by a 33% reduction in LPL: 13.1 ± 5.1 vs 18.9 ± 4.7 ng/ml. Obese participants had 25% lower adiponectin 2.9 (1.9-3.8) vs 4.4 (3.2.-5.2) μg/ml; 260% higher leptin 25.7 (11.2-44.8) vs 9.3 (2.8-20.7) ng/ml and 83% higher Il-6: 2.2 (1.3-5.4) vs 1.2 (0.8-1.4) pg/ml. ApoC-III and ANGPTL3 correlated positively with VAI; ANGPTL3 negatively with HDL-C; LDL size and VLDL-C. ApoB48 correlated negatively with LDL-C.
Adolescents with obesity show higher ANGPTL3 compounded with increased apoC-III associated with increased CR and lower LPL mass. This is associated with inflammation and visceral fat. The significance of these findings resides in that they shed light on a mechanism for TRL dyslipidemia in adolescents: increased LPL inhibition impairs VLDL and chylomicron catabolism leading to atherogenic remnants.
我们推测肥胖青少年的残余B48浓度较高，这与脂蛋白脂肪酶失调有关。
对32名肥胖青少年和27名对照受试者进行横断面研究。
与瘦对照组相比，肥胖参与者的载脂蛋白B48浓度高35%：分别为3.60（2.93 - 4.30）与2.65（1.64 - 3.68）ng/ml；载脂蛋白C-III高28%：分别为72.7（58.6 - 89.7）与56.9（44.8 - 79.8）μg/ml，血管生成素样蛋白3（ANGPTL 3）高17%：分别为72.2 ± 20.2与61.2 ± 19.2 ng/ml。同时脂蛋白脂肪酶（LPL）降低了33%：分别为13.1 ± 5.1与18.9 ± 4.7 ng/ml。肥胖参与者的脂联素降低25%：分别为2.9（1.9 - 3.8）与4.4（3.2 - 5.2）μg/ml；瘦素高260%：分别为25.7（11.2 - 44.8）与9.3（2.8 - 20.7）ng/ml，白细胞介素-6（Il-6）高83%：分别为2.2（1.3 - 5.4）与1.2（0.8 - 1.4）pg/ml。载脂蛋白C-III和ANGPTL3与内脏脂肪指数（VAI）呈正相关；ANGPTL3与高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白大小和极低密度脂蛋白胆固醇（VLDL-C）呈负相关。载脂蛋白B48与低密度脂蛋白胆固醇（LDL-C）呈负相关。
肥胖青少年的ANGPTL3升高，同时载脂蛋白C-III增加，伴有C反应蛋白（CR）升高和LPL质量降低。这与炎症和内脏脂肪有关。这些发现的意义在于揭示了青少年甘油三酯丰富的脂蛋白（TRL）血脂异常的机制：LPL抑制增加损害了极低密度脂蛋白和乳糜微粒的分解代谢，导致致动脉粥样硬化的残余物。
