Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Nitric Oxide. 2020 Aug 1;100-101:45-49. doi: 10.1016/j.niox.2020.05.001. Epub 2020 May 12.
Fractional exhaled nitric oxide levels are related to various clinical diseases. This study investigated the associations between the clinical characteristics and the level of fractional exhaled nitric oxide in patients with adult congenital heart disease.
Fractional exhaled nitric oxide values were measured in 30 adult patients with stable congenital heart disease who had undergone right heart catheterization and 17 healthy individuals (controls). There was no significant difference in fractional exhaled nitric oxide values between patients with congenital heart disease and healthy controls. Depending on whether their fractional exhaled nitric oxide values were above or below the median value, patients with congenital heart disease were divided into two groups (low vs. high fractional exhaled nitric oxide groups). The relationship between fractional exhaled nitric oxide values and clinical characteristics was investigated. There was a higher percentage of patients with cyanosis in the low fractional exhaled nitric oxide group (50%) than in the high fractional exhaled nitric oxide group (7.1%). There was no significant difference in right heart catheterization data between the low and high fractional exhaled nitric oxide groups. The fractional exhaled nitric oxide value was correlated to the number of neutrophils in patients with cyanosis (r = 0.84 (N = 8), p = 0.005).
In this cohort of patients with adult congenital heart disease, lower levels of fractional exhaled nitric oxide corresponded to the presence of cyanosis.
呼出气一氧化氮分数与各种临床疾病有关。本研究探讨了成人先天性心脏病患者的临床特征与呼出气一氧化氮分数水平之间的关系。
对 30 例接受右心导管检查的稳定型先天性心脏病成年患者和 17 名健康个体（对照组）进行呼出气一氧化氮分数值测量。先天性心脏病患者与健康对照组的呼出气一氧化氮分数值无显著差异。根据呼出气一氧化氮分数值是否高于或低于中位数，将先天性心脏病患者分为两组（低呼出气一氧化氮分数组与高呼出气一氧化氮分数组）。研究了呼出气一氧化氮分数值与临床特征之间的关系。低呼出气一氧化氮分数组（50%）中发绀患者的比例高于高呼出气一氧化氮分数组（7.1%）。低呼出气一氧化氮分数组与高呼出气一氧化氮分数组之间的右心导管检查数据无显著差异。发绀患者的呼出气一氧化氮分数值与中性粒细胞数呈正相关（r = 0.84（N = 8），p = 0.005）。
在本队列的成人先天性心脏病患者中，较低的呼出气一氧化氮分数与发绀的存在相关。
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