[1例胰腺癌化疗期间粒细胞集落刺激因子所致的主动脉炎]

[A Case of Aortitis Caused by a Granulocyte-Colony-Stimulating Factor during Chemotherapy for Pancreatic Cancer].

作者信息

Miyazaki Kento, Takadate Tatsuyuki, Motoi Fuyuhiko, Kamei Takashi, Naitoh Takeshi, Unno Michiaki

机构信息

Dept. of Surgery, Tohoku University Graduate School of Medicine.

出版信息

Gan To Kagaku Ryoho. 2020 May;47(5):851-853.

PMID:32408335

Abstract

BACKGROUND

Pegfilgrastim, a long-acting granulocyte-colony-stimulating factor(G-CSF), has been used as prophylaxis for severe hematotoxicity induced by chemotherapy. We report a case of aortitis induced by pegfilgrastim administration during modified FOLFIRINOX(mFOLFIRINOX)chemotherapy for metastatic pancreatic cancer.

CASE REPORT

A 65-year-old woman underwent a distal pancreatectomy for pancreatic tail cancer. Liver metastases appeared 2 years after the surgery. mFOLFIRINOX chemotherapy was started with prophylactic administration of pegfilgrastim. Eight days after the first administration and 6 days after administration of the 8th course, the patient developed a fever. The blood test results indicated severe inflammation. Computed tomography revealed a thickened aorta indicating aortitis. The symptoms rapidly improved with antibiotic therapy. We diagnosed aortitis induced by pegfilgrastim administration.

CONCLUSION

Aortitis should be considered when a patient has unidentified inflammatory findings after receiving pegfilgrastim.

摘要

背景

聚乙二醇化重组人粒细胞刺激因子（pegfilgrastim），一种长效粒细胞集落刺激因子（G-CSF），已被用于预防化疗引起的严重血液毒性。我们报告了1例在转移性胰腺癌的改良FOLFIRINOX（mFOLFIRINOX）化疗期间因使用pegfilgrastim而诱发主动脉炎的病例。

病例报告

一名65岁女性因胰尾癌接受了胰体尾切除术。术后2年出现肝转移。开始mFOLFIRINOX化疗并预防性使用pegfilgrastim。首次给药8天后以及第8疗程给药6天后，患者出现发热。血液检查结果显示严重炎症。计算机断层扫描显示主动脉增厚，提示主动脉炎。经抗生素治疗后症状迅速改善。我们诊断为pegfilgrastim给药诱发的主动脉炎。