Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan.
Department of Radiology, Graduate School of Medicine, The University of Tokyo, Japan.
Intern Med. 2023;62(11):1647-1652. doi: 10.2169/internalmedicine.0599-22. Epub 2023 Jun 1.
We herein report an 83-year-old woman with filgrastim-associated aortitis during chemotherapy for relapsed diffuse large B-cell lymphoma. She had been treated with filgrastim as a prophylaxis for neutropenia during the fourth cycle of chemotherapy from day 9 to 18. On day 21, she developed a fever. Contrast-enhanced computed tomography revealed aortitis of the descending aorta. The fever abated with non-steroidal anti-inflammatory drug treatment. A literature review identified a small number of aortitis cases all caused by prophylactic use of granulocyte colony-stimulating factors (G-CSFs), among which short-acting filgrastim was rarely encountered. The present and previous findings imply a possible relationship between aortitis and prophylactic G-CSF usage.
我们在此报告一例 83 岁女性，在接受复发弥漫性大 B 细胞淋巴瘤化疗期间发生粒细胞集落刺激因子（filgrastim）相关性主动脉炎。她在第 4 周期化疗的第 9 天至第 18 天接受 filgrastim 作为预防中性粒细胞减少症的药物。第 21 天，她出现发热。增强 CT 显示降主动脉炎。非甾体类抗炎药治疗后发热消退。文献复习发现少数几例主动脉炎病例均由粒细胞集落刺激因子（G-CSF）预防性使用引起，其中很少见到短效 filgrastim。目前和以前的发现提示主动脉炎与预防性 G-CSF 使用之间可能存在关联。
