Department of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba, Japan.
Department of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba, Japan.
J Infect Chemother. 2020 Jul;26(7):749-751. doi: 10.1016/j.jiac.2020.02.009. Epub 2020 May 12.
The non-encapsulated Streptococcus pneumoniae (NESp) has emerged and increased in the clinical setting. The majority of NESp strains have been isolated from the nasopharynxes of healthy carriers and from respiratory specimens of patients with otitis media. NESp strains were shown to be more effective than encapsulated counterparts at forming biofilms. Therefore, NESp should become one of the leading causes of emerging refractory respiratory disease after the introduction of pneumococcal conjugate vaccines. We report the first case of multidrug-resistant - including fluoroquinolone-resistant - NESp isolated from the intrabronchial aspirate of a patient with pneumonia. Drug-resistant NESp infections can possibly emerge as a clinical problem and thus the continuous monitoring of NESp infections is of utmost importance.
非囊膜型肺炎链球菌（NESp）在临床环境中已经出现并增多。大多数 NESp 菌株已从健康带菌者的鼻咽部和中耳炎患者的呼吸道标本中分离出来。研究表明，与囊膜型肺炎链球菌相比，NESp 菌株更能有效地形成生物膜。因此，在肺炎球菌结合疫苗问世后，NESp 应该成为新兴难治性呼吸道疾病的主要原因之一。我们报告了首例从肺炎患者支气管肺泡灌洗液中分离出的对包括氟喹诺酮类药物在内的多种药物耐药的 NESp。耐药性 NESp 感染可能会成为一个临床问题，因此持续监测 NESp 感染至关重要。
