Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
J Mater Chem B. 2020 Jul 7;8(25):5380-5394. doi: 10.1039/d0tb00477d. Epub 2020 May 15.
Polypeptoids are biocompatible, synthetically accessible, chemically and enzymatically stable, chemically diverse, and structurally controllable. As a bioinspired and biomimetic material, it has attracted considerable attention due to its great potential in biological applications including drug and gene delivery, sensing, imaging, molecular recognition, and anti-cancer therapy. Diblock copolypeptoids have especially been of increasing interest in the materials chemistry community because of their capacity to microphase separate and self-assemble to form a variety of nanoarchitectures. This review will discuss recent studies on diblock copolypeptoids regarding their synthesis, microphase separation, crystallization, self-assembly, and biological applications.
多肽类似物具有生物相容性、可合成、化学和酶学稳定性、化学多样性以及结构可控性。作为一种受生物启发和仿生的材料，由于其在药物和基因传递、传感、成像、分子识别和抗癌治疗等生物应用方面的巨大潜力，多肽类似物引起了相当大的关注。由于其微相分离和自组装形成各种纳米结构的能力，两亲性嵌段多肽类似物在材料化学领域尤其受到越来越多的关注。本文将讨论关于两亲性嵌段多肽类似物的最新研究进展，包括其合成、微相分离、结晶、自组装以及生物应用。
