Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India.
Org Biomol Chem. 2020 May 27;18(20):3853-3857. doi: 10.1039/d0ob00740d.
A sustainable approach which works under catalyst- and solvent-free conditions for the synthesis of structurally diverse secondary amines has been uncovered. This one-pot protocol works efficiently at room temperature and is compatible with a wide range of sterically and electronically diverse aldehydes and primary amines. Notably, this simple process offers scalability, excellent functional group tolerance, chemoselectivity, and is also effective at the synthesis of biologically relevant molecules.
现已发现一种在无催化剂和溶剂条件下合成结构多样的仲胺的可持续方法。该一锅法在室温下高效运行，并且与广泛的空间和电子不同的醛和伯胺兼容。值得注意的是，这种简单的过程具有可扩展性、出色的官能团耐受性、化学选择性，并且在合成生物相关分子方面也很有效。
