A dosimetric comparison of flattening filter free and conventional VMAT treatments for some common cancer sites.

The aim of this study was to assess the potential for treating various common cancer sites with flattening filter free (FFF) rather than conventionally flattened (cFF) treatment plans considering both in-field and out-of-field dosimetry. This study seeks to extend previous work by others to the Elekta Agility VMAT treatments commonly used at our clinic. Nine matched pairs of conventional and FFF 6X treatment plans for prostate, head and neck, and brain cancer sites were generated using the Monaco treatment planning system (Elekta AB, Stockholm, Sweden). Absorbed dose distribution statistics for target and healthy tissue volumes reported by the Monaco treatment planning system were compared. One matched pair of plans for each cancer site was experimentally validated by film and ion chamber measurements in an anthropomorphic phantom. Head leakage was measured at various positions in a small water tank and corrections made to the out-of-field dose distributions calculated by the treatment planning system. Out-of-field organ doses and effective whole body doses were calculated according to ICRP103 (Charles in Radiat Prot Dosim 129:500-507, 2008). The in-field target and organ dose statistics for the cFF and FFF plans were comparable whereas the out-of-field organ and whole body effective doses for plans delivered using 6X FFF were generally lower than those delivered with 6X cFF. A modest increase in monitor unit (MU) delivery rates was also observed with the FFF beams. We conclude that treatment plan delivery using FFF rather than cFF beams is feasible and may provide benefits in terms of reduced out-of-field doses and secondary cancer risks for some patients.