Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan.
J Plant Res. 2020 Jul;133(4):471-478. doi: 10.1007/s10265-020-01202-2. Epub 2020 May 14.
The centromere and telomere are universal heterochromatic domains; however, the proper positioning of those domains in nuclear space during the mitotic interphase differs among eukaryotes. Consequently, the question arises how and why this difference occurs. Studies over the past 2 decades have identified several nuclear membrane proteins, nucleolar proteins, and the structural maintenance of a chromosome complex as factors involved in the positional control of centromeres and/or telomeres during the mitotic interphase in yeasts, animals, and plants. In this review, with a primary focus on plants, the roles of those factors are summarized, and the biological significance of proper centromere and telomere positionings during the mitotic interphase is discussed in an effort to provide guidance for this question.
着丝粒和端粒是普遍的异染色质结构域；然而，在有丝分裂间期，这些结构域在核空间中的正确定位在真核生物中有所不同。因此，出现了这样一个问题：这种差异是如何以及为什么发生的。在过去的 20 年中，研究已经确定了几种核膜蛋白、核仁蛋白和染色体结构维持复合物作为参与酵母、动物和植物有丝分裂间期着丝粒和/或端粒位置控制的因素。在这篇综述中，我们主要关注植物，总结了这些因素的作用，并讨论了有丝分裂间期适当的着丝粒和端粒定位的生物学意义，以期为这个问题提供指导。
