ElGhareeb Mohamed Ibrahim, Metwalli Mohamed, AbdelMoneim Nehal
Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Resident Dermatologist, Alhaud Almarsoud hospital, Egypt.
Dermatol Ther. 2020 Jul;33(4):e13586. doi: 10.1111/dth.13586. Epub 2020 May 28.
This study aimed to compare the efficacy and safety of oral methotrexate (MTX) and oral mini-pulse (OMP) dexamethasone alone and in combination in the treatment of vitiligo. A total of 42 patients with vitiligo were included in the study. The patients were treated for three months and randomly assigned into three groups including 14 patients each: group A received oral MTX, group B received OMP dexamethasone, and group C received a combination of both. Follow-up was performed using digital photographs, Vitiligo European Task Force score, and dermoscopy. Disease extension significantly decreased in group C compared with that in groups A (P < .001) and B (P < .05). The frequency of intralesional pigmentation significantly increased (P < .05) in groups A and C and decreased (P < .05) in group B posttreatment noted using a dermoscope. Moreover, the frequency of micro-Koebner's phenomenon and starburst pattern significantly decreased (P < .05) in groups B and C and that of tapioca sago in group C only posttreatment.
本研究旨在比较口服甲氨蝶呤（MTX）和口服小剂量脉冲（OMP）地塞米松单独及联合应用治疗白癜风的疗效和安全性。共有42例白癜风患者纳入本研究。患者接受为期三个月的治疗，并随机分为三组，每组14例：A组接受口服MTX，B组接受OMP地塞米松，C组接受两者联合治疗。采用数码照片、白癜风欧洲工作组评分和皮肤镜进行随访。与A组（P <.001）和B组（P <.05）相比，C组疾病扩展明显减少。使用皮肤镜观察发现，治疗后A组和C组皮损内色素沉着频率显著增加（P <.05），B组则降低（P <.05）。此外，治疗后B组和C组微Koebner现象和星芒状模式频率显著降低（P <.05），仅C组的木薯西米样模式频率降低。
