Department of Environmental Toxicology, The Institute of Environmental and Human Health (TIEHH), Texas Tech University, Lubbock, TX 79416, United States.
Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau, China.
Curr Drug Targets. 2020;21(11):1084-1098. doi: 10.2174/1389450121666200514222900.
This review summarizes the epigenetic mechanisms of deoxyribonucleic acid (DNA) methylation, histone modifications in cancer and the epigenetic modifications in cancer therapy. Due to their undesired side effects, the use of epigenetic drugs as chemo-drugs in cancer therapies is limited. The drug delivery system opens a door for minimizing these side effects and achieving greater therapeutic benefits. The limitations of current epigenetic therapies in clinical cancer treatment and the advantages of using drug delivery systems for epigenetic agents are also discussed. Combining drug delivery systems with epigenetic therapy is a promising approach to reaching a high therapeutic index and minimizing the side effects.
这篇综述总结了脱氧核糖核酸（DNA）甲基化、癌症中的组蛋白修饰以及癌症治疗中的表观遗传修饰的表观遗传机制。由于其不理想的副作用，将表观遗传药物作为癌症治疗中的化疗药物的应用受到限制。药物输送系统为最小化这些副作用并实现更大的治疗效益开辟了道路。还讨论了当前表观遗传疗法在临床癌症治疗中的局限性以及药物输送系统用于表观遗传药物的优势。将药物输送系统与表观遗传疗法相结合是实现高治疗指数和最小化副作用的有前途的方法。
