夏威夷的并指畸形：对三个不同种族谱系的研究

Symphalangism in Hawaii: a study of three distinct ethnic pedigrees.

作者信息

Gaal S A, Doyle J R, Larsen I J

机构信息

Department of Surgery, John A. Burns School of Medicine, University of Hawaii, Honolulu.

出版信息

J Hand Surg Am. 1988 Sep;13(5):783-7. doi: 10.1016/s0363-5023(88)80148-5.

DOI:10.1016/s0363-5023(88)80148-5

PMID:3241059

Abstract

Symphalangism was introduced into Hawaii by a Cherokee Indian in the late 1800s. The resultant pedigree, along with two other racially distinct pedigrees, confirms that the condition is an autosomal dominant genetic trait. Associated conditions include carpal and tarsal coalitions, cervical fusions, brachydactylism, symphalangism of the toes, and hearing loss. Surgical intervention in the hands is seldom, if ever, indicated but correction of the associated hearing loss is rewarding.

摘要

并指畸形于19世纪末由一位切罗基印第安人引入夏威夷。由此产生的家系，连同另外两个种族不同的家系，证实了这种情况是一种常染色体显性遗传特征。相关病症包括腕骨和跗骨联合、颈椎融合、短指畸形、脚趾并指畸形以及听力丧失。手部很少需要手术干预，但矫正相关的听力丧失是有成效的。