Department of Physical Medicine and Rehabilitation, Health Sciences University Ankara Training and Research Hospital, Ankara, Turkey.
BMC Musculoskelet Disord. 2020 May 14;21(1):300. doi: 10.1186/s12891-020-03290-6.
Isotretinoin (ISO) is a synthetic vitamin A derivative which has been used for treatment-resistant acne vulgaris. Although most musculoskeletal side effects of ISO are common, including myalgia, arthralgia, and back pain, sacroiliitis is one of the uncommon side effects. ISO-induced sacroiliitis usually completely resolves within a few months by the cessation of the drug.
In this paper, we present a 26-year-old female patient with chronic sacroiliitis that was probably induced by ISO and not resolved by the discontinuation of the drug.
In this patient, sacroiliitis was overlooked for three years. Therefore, ISO usage should be considered in the differential diagnosis of sacroiliitis and low back pain.
异维 A 酸（ISO）是一种合成的维生素 A 衍生物，已被用于治疗耐药性寻常痤疮。虽然 ISO 的大多数肌肉骨骼副作用很常见，包括肌痛、关节痛和背痛，但骶髂关节炎是其不常见的副作用之一。ISO 诱导的骶髂关节炎通常通过停药在几个月内完全缓解。
本文报道了一例 26 岁女性慢性骶髂关节炎患者，可能由 ISO 引起，停药后未缓解。
在本例患者中，骶髂关节炎被忽视了三年。因此，在骶髂关节炎和腰痛的鉴别诊断中应考虑 ISO 的使用。
Zotero 插件