儿童肠道病毒相关的严重急性弛缓性脊髓炎：两种演变模式对应两种表型？
Severe Acute Flaccid Myelitis Associated With Enterovirus in Children: Two Phenotypes for Two Evolution Profiles?
作者信息
Aubart Melodie, Gitiaux Cyril, Roux Charles Joris, Levy Raphael, Schuffenecker Isabelle, Mirand Audrey, Bach Nathalie, Moulin Florence, Bergounioux Jean, Leruez-Ville Marianne, Rozenberg Flore, Sterlin Delphine, Musset Lucile, Antona Denise, Boddaert Nathalie, Zhang Shen Ying, Kossorotoff Manoelle, Desguerre Isabelle
机构信息
Department of Paediatric Neurology, Necker-Enfants malades Hospital, University of Paris, AP-HP, Paris, France.
INSERM 1163, Imagine Institute, Paris, France.
出版信息
Front Neurol. 2020 Apr 28;11:343. doi: 10.3389/fneur.2020.00343. eCollection 2020.
Acute flaccid myelitis (AFM) is an acute paralysis syndrome defined by a specific inflammation of the anterior horn cells of the spinal cord. From 2014, worrying waves of life-threatening AFM consecutive to enterovirus infection (EV-D68 and EV-A71) have been reported. We describe 10 children displaying an AFM with an EV infection, the treatments performed and the 1 to 3-years follow-up. Two groups of patients were distinguished: 6 children ("") had severe motor disability whereas 4 other children ("") displayed severe brainstem weakness requiring ventilation support. Electrodiagnostic studies ( = 8) support the presence of a motor neuronopathy associated to myelitis. The best prognosis factor seems to be the motor recovery after the first 4 weeks of the disease.
急性弛缓性脊髓炎（AFM）是一种由脊髓前角细胞特定炎症所定义的急性麻痹综合征。自2014年以来，已有报告称出现了与肠道病毒感染（肠道病毒D68型和肠道病毒A71型）相关的危及生命的AFM病例令人担忧地接连出现。我们描述了10例患有AFM且伴有肠道病毒感染的儿童、所实施的治疗以及1至3年的随访情况。区分出了两组患者：6名儿童（“组1”）有严重运动功能障碍，而另外4名儿童（“组2”）表现出严重脑干无力需要通气支持。电诊断研究（n = 8）支持存在与脊髓炎相关的运动神经元病。最佳预后因素似乎是疾病最初4周后的运动恢复情况。
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