急诊科疑似肺栓塞患者中copeptin的诊断价值

Diagnostic Value of Copeptin in Patients with Suspected Pulmonary Embolism in Emergency Departments.

作者信息

Abootalebi Ghahnavieh Alireza, Golshani Keihan, Jafarpisheh Mohammadsaleh, Moaiednia Milad, Memarzade Mohammad Ali, Maghami-Mehr Asieh

机构信息

Emergency Medicine Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Hezarjarib Ave, Isfahan, Iran.

Department of Statistics, Payam Noor University, Shiraz, Iran.

出版信息

Tanaffos. 2019 Mar;18(3):262-267.

PMID:32411267

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7210577/

Abstract

BACKGROUND

Pulmonary thromboembolism (PTE) is a serious and life-threatening condition. Diagnosis of PTE can be challenging in emergency departments, as there is no absolutely reliable biomarker for the diagnosis of PTE. Copeptin (COP) is a new biomarker, which may be valuable in the diagnosis of PTE; however, its role has not been well studied. In this study, we aimed to investigate the diagnostic value of COP in the diagnosis of PTE.

MATERIALS AND METHODS

This study was carried out on 102 patients suspected of PTE. The serum levels of D-dimer and COP were measured, and diagnosis of PTE was confirmed by CT angiography. Next, the prognostic value of D-dimer and COP was examined.

RESULTS

The area under the curve (AUC) of D-dimer was 0.581 with a standard error (SE) of 0.07 (P=0.34). Estimation of the validity of D-dimer showed that it is a highly sensitive (100%), but poorly specific (15.8%) test. Evaluation of the predictive value of this test showed that it has a positive predictive value of 20% and a negative predictive value of 100%. The AUC of COP was 0.423 with SE of 0.1 (P=0.44). Measurement of the validity of COP test showed that it is a poorly sensitive (50%) and specific (22.9%) test.

CONCLUSION

COP is a new cardiovascular biomarker. However, the present findings did not confirm the prognostic value of this biomarker for the diagnosis of PTE.

摘要

背景

肺血栓栓塞症（PTE）是一种严重且危及生命的疾病。在急诊科，PTE的诊断可能具有挑战性，因为尚无绝对可靠的生物标志物用于PTE的诊断。 copeptin（COP）是一种新的生物标志物，可能对PTE的诊断有价值；然而，其作用尚未得到充分研究。在本研究中，我们旨在探讨COP在PTE诊断中的诊断价值。

材料与方法

本研究对102例疑似PTE的患者进行。测量D-二聚体和COP的血清水平，并通过CT血管造影确诊PTE。接下来，检查D-二聚体和COP的预后价值。

结果

D-二聚体的曲线下面积（AUC）为0.581，标准误差（SE）为0.07（P = 0.34）。D-二聚体有效性评估表明，它是一种高度敏感（100%）但特异性较差（15.8%）的检测方法。该检测方法预测价值评估显示，其阳性预测值为20%，阴性预测值为100%。COP的AUC为0.423，SE为0.1（P = 0.44）。COP检测有效性测量表明，它是一种敏感性较差（50%）且特异性（22.9%）的检测方法。