与卡尔曼综合征相关的代谢组学改变。
Metabolomic alterations associated with Kallmann syndrome.
作者信息
Guo Ye, Li Xiaogang, Yan Songxin, Li Yongzhe
机构信息
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Medical Science Research Center, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
出版信息
Ann Transl Med. 2020 Apr;8(8):529. doi: 10.21037/atm.2020.04.03.
BACKGROUND
This study was conducted to identify potential seminal plasma metabolic markers associated with disease activity in Kallmann syndrome (KS).
METHODS
We collected medical records and seminal plasma samples from 17 KS patients and 20 age-matched healthy controls (HC) and performed metabolomics analysis using the UPLC-QTOF-MS method.
RESULTS
Partial least squares discriminant analysis (PLS-DA) showed that the metabolomics profile of KS patients was clearly separated from HC. Statistical analysis of the data indicates that there are differential metabolites between KS patients and HC. The main metabolic pathways focus on linoleic acid (LA) metabolism, Glycerophospholipid metabolism.
CONCLUSIONS
The seminal plasma metabolomics profile of KS patients has changed. Glycerophospholipids and LA are promising biomarkers for KS diagnosis.
背景
本研究旨在确定与卡尔曼综合征（KS）疾病活动相关的潜在精浆代谢标志物。
方法
我们收集了17例KS患者和20例年龄匹配的健康对照（HC）的病历和精浆样本，并使用超高效液相色谱-四极杆飞行时间质谱（UPLC-QTOF-MS）方法进行代谢组学分析。
结果
偏最小二乘判别分析（PLS-DA）表明，KS患者的代谢组学图谱与HC明显分离。数据统计分析表明，KS患者和HC之间存在差异代谢物。主要代谢途径集中在亚油酸（LA）代谢、甘油磷脂代谢。
结论
KS患者的精浆代谢组学图谱发生了变化。甘油磷脂和LA有望成为KS诊断的生物标志物。
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