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Early Experience With Eravacycline for Complicated Infections.依拉环素用于复杂感染的早期经验
Open Forum Infect Dis. 2020 Mar 2;7(5):ofaa071. doi: 10.1093/ofid/ofaa071. eCollection 2020 May.
2
Evaluation of Eravacycline: A Novel Fluorocycline.评估依拉环素:一种新型氟环素。
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Eravacycline: a new treatment option for complicated intra-abdominal infections in the age of multidrug resistance.依拉环素:多重耐药时代治疗复杂性腹腔内感染的新选择。
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本文引用的文献

1
Evaluation of Eravacycline: A Novel Fluorocycline.评估依拉环素:一种新型氟环素。
Pharmacotherapy. 2020 Mar;40(3):221-238. doi: 10.1002/phar.2366. Epub 2020 Feb 21.
2
IGNITE4: Results of a Phase 3, Randomized, Multicenter, Prospective Trial of Eravacycline vs Meropenem in the Treatment of Complicated Intraabdominal Infections.IGNITE4 研究:依拉环素对比美罗培南治疗复杂性腹腔内感染的 3 期、随机、多中心、前瞻性试验结果。
Clin Infect Dis. 2019 Aug 30;69(6):921-929. doi: 10.1093/cid/ciy1029.
3
The efficacy and safety of tigecycline for the treatment of bloodstream infections: a systematic review and meta-analysis.替加环素治疗血流感染的疗效与安全性:一项系统评价和荟萃分析。
Ann Clin Microbiol Antimicrob. 2017 Apr 5;16(1):24. doi: 10.1186/s12941-017-0199-8.
4
Assessing the Efficacy and Safety of Eravacycline vs Ertapenem in Complicated Intra-abdominal Infections in the Investigating Gram-Negative Infections Treated With Eravacycline (IGNITE 1) Trial: A Randomized Clinical Trial.评估依拉环素与厄他培南治疗复杂性腹腔内感染的疗效和安全性:一项针对革兰氏阴性感染的依拉环素治疗(IGNITE 1)试验:随机临床试验。
JAMA Surg. 2017 Mar 1;152(3):224-232. doi: 10.1001/jamasurg.2016.4237.
5
Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent.新型氟环素抗菌药物依拉环素综述
Drugs. 2016 Apr;76(5):567-88. doi: 10.1007/s40265-016-0545-8.
6
The efficacy and safety of tigecycline for the treatment of complicated intra-abdominal infections: analysis of pooled clinical trial data.替加环素治疗复杂性腹腔内感染的疗效和安全性:汇总临床试验数据分析
Clin Infect Dis. 2005 Sep 1;41 Suppl 5:S354-67. doi: 10.1086/431676.
7
Reappraisal of community-acquired bacteremia: a proposal of a new classification for the spectrum of acquisition of bacteremia.社区获得性菌血症的重新评估:关于菌血症获得谱的新分类建议
Clin Infect Dis. 2002 Jun 1;34(11):1431-9. doi: 10.1086/339809. Epub 2002 Apr 30.
8
APACHE II: a severity of disease classification system.急性生理与慢性健康状况评分系统II:一种疾病严重程度分类系统。
Crit Care Med. 1985 Oct;13(10):818-29.

依拉环素用于复杂感染的早期经验

Early Experience With Eravacycline for Complicated Infections.

作者信息

Alosaimy Sara, Molina Kyle C, Claeys Kimberly C, Andrade Justin, Truong James, King Madeline A, Pullinger Benjamin M, Huang Glen, Morrisette Taylor, Lagnf Abdalhamid M, Davis Susan L, Rybak Michael J

机构信息

Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit ,Michigan, USA.

University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado, USA.

出版信息

Open Forum Infect Dis. 2020 Mar 2;7(5):ofaa071. doi: 10.1093/ofid/ofaa071. eCollection 2020 May.

DOI:10.1093/ofid/ofaa071
PMID:32411809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7210802/
Abstract

Eravacycline (ERV) was used in 35 patients for various infections. The most common pathogen was and 30-day survival was 74%. Absence of 30-day recurrence and resolution of signs and symptoms of infection were 91% and 57%, respectively. ERV was well-tolerated, with adverse events leading to drug discontinuation in one patient.

摘要

依拉环素(ERV)用于35例患有各种感染的患者。最常见的病原体是[此处原文缺失相关内容],30天生存率为74%。30天无复发以及感染体征和症状消退的比例分别为91%和57%。依拉环素耐受性良好,仅有1例患者因不良事件导致停药。