Jonker G J, de Zeeuw D, Huisman R M, van der Hem G K
Department of Internal Medicine, State University Hospital, Groningen, The Netherlands.
J Hypertens Suppl. 1988 Dec;6(4):S455-7. doi: 10.1097/00004872-198812040-00143.
We performed experiments in the two-kidney, one clip Goldblatt hypertensive dog to see whether angiotensin converting enzyme (ACE) inhibition could improve the sensitivity of hippurate renography in detecting renal artery stenosis. Ten dogs on a sodium-restricted diet were studied before and after induction of a renal artery stenosis. In the absence of renal artery stenosis nine dogs showed normal renograms before ACE inhibition, and one was false positive. During ACE inhibition all 10 renograms were normal. With a renal artery stenosis 50% of the renograms were false negative, whereas a 100% sensitivity was reached during ACE inhibition. The alterations induced by the ACE inhibition on the renograms were not related to changes in renal blood flow. In conclusion, ACE inhibition markedly improved the sensitivity of hippurate renography in the two-kidney, one clip dog.
我们在双肾单夹型戈德布拉特高血压犬身上进行了实验，以观察血管紧张素转换酶（ACE）抑制是否能提高马尿酸盐肾图检测肾动脉狭窄的敏感性。对10只限制钠饮食的犬在诱导肾动脉狭窄前后进行了研究。在没有肾动脉狭窄的情况下，9只犬在ACE抑制前肾图正常，1只出现假阳性。在ACE抑制期间，所有10只犬的肾图均正常。存在肾动脉狭窄时，50%的肾图为假阴性，而在ACE抑制期间敏感性达到100%。ACE抑制引起的肾图改变与肾血流量变化无关。总之，ACE抑制显著提高了双肾单夹型犬马尿酸盐肾图的敏感性。
