慢性血管紧张素转换酶抑制对肾血管性高血压肾图诊断价值的影响：初步报告

Effect of chronic ACE inhibition on the diagnostic value of renography for renovascular hypertension: a preliminary report.

作者信息

Visscher C A, de Zeeuw D, Huisman R M

机构信息

Department of Medicine, Groningen Institute for Drug Studies (GIDS), University Hospital, The Netherlands.

出版信息

Nephrol Dial Transplant. 1995;10(2):263-5.

Abstract

We compared the effects of acute and chronic ACE inhibition (ACEi) on the 123I-hippurate in the stenotic kidney of two 2-kidney, 1-clip hypertensive dogs. In the period after clip implantation poststenotic renograms without ACEi of both dogs were normal. Acute ACEi always resulted in delayed hippurate handling. Chronic ACEi, however, induced abnormal poststenotic renograms in only 36% of the cases. Withdrawal of chronic ACEi restored the phenomenon of acute ACE-induced delayed hippurate handling within 5 months in both dogs. These data indicate that chronic ACEi or recent ACEi medication reduces the effectiveness of ACEi renography in diagnosing hypertension due to a moderate renal-artery stenosis. This phenomenon may explain why the sensitivity of ACEi renography in human studies varies more than in animal studies.

摘要

我们比较了急性和慢性血管紧张素转换酶抑制（ACEi）对两只双肾单夹高血压犬狭窄肾脏中123I-马尿酸盐的影响。在夹闭植入后的时期，两只犬未使用ACEi时的狭窄后肾图均正常。急性ACEi总是导致马尿酸盐处理延迟。然而，慢性ACEi仅在36%的病例中诱导出异常的狭窄后肾图。停用慢性ACEi后，两只犬在5个月内均恢复了急性ACE诱导的马尿酸盐处理延迟现象。这些数据表明，慢性ACEi或近期的ACEi药物治疗会降低ACEi肾图在诊断中度肾动脉狭窄所致高血压中的有效性。这一现象可能解释了为什么在人体研究中ACEi肾图的敏感性变化比动物研究中更大。