School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, Singapore 639798, Singapore.
National Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, Singapore.
Int J Mol Sci. 2020 May 13;21(10):3444. doi: 10.3390/ijms21103444.
Advances in material science and innovative medical technologies have allowed the development of less invasive interventional procedures for deploying implant devices, including scaffolds for cardiac tissue engineering. Biodegradable materials (e.g., resorbable polymers) are employed in devices that are only needed for a transient period. In the case of coronary stents, the device is only required for 6-8 months before positive remodelling takes place. Hence, biodegradable polymeric stents have been considered to promote this positive remodelling and eliminate the issue of permanent caging of the vessel. In tissue engineering, the role of the scaffold is to support favourable cell-scaffold interaction to stimulate formation of functional tissue. The ideal outcome is for the cells to produce their own extracellular matrix over time and eventually replace the implanted scaffold or tissue engineered construct. Synthetic biodegradable polymers are the favoured candidates as scaffolds, because their degradation rates can be manipulated over a broad time scale, and they may be functionalised easily. This review presents an overview of coronary heart disease, the limitations of current interventions and how biomaterials can be used to potentially circumvent these shortcomings in bioresorbable stents, vascular grafts and cardiac patches. The material specifications, type of polymers used, current progress and future challenges for each application will be discussed in this manuscript.
材料科学和创新医疗技术的进步使得能够开发出更具侵入性的介入性程序来部署植入设备,包括心脏组织工程的支架。可生物降解材料(例如可吸收聚合物)用于仅在短暂时间内需要的设备中。在冠状动脉支架的情况下,在发生积极重塑之前,该设备仅需要 6-8 个月。因此,已经考虑使用可生物降解的聚合物支架来促进这种积极的重塑并消除血管永久笼状的问题。在组织工程中,支架的作用是支持有利的细胞-支架相互作用,以刺激功能性组织的形成。理想的结果是随着时间的推移细胞产生自己的细胞外基质并最终取代植入的支架或组织工程构建体。合成可生物降解聚合物是作为支架的首选候选物,因为它们的降解速率可以在广泛的时间范围内进行控制,并且可以很容易地进行功能化。本综述介绍了冠心病、当前干预措施的局限性以及生物材料如何可用于潜在地规避生物可吸收支架、血管移植物和心脏补片在可生物降解支架中的这些缺点。本文将讨论每种应用的材料规格、使用的聚合物类型、当前进展和未来挑战。