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展望不久的将来:来自哺乳动物和昆虫细胞的人造肉

A Glance into the Near Future: Cultivated Meat from Mammalian and Insect Cells.

作者信息

Giglio Fabiana, Scieuzo Carmen, Ouazri Sofia, Pucciarelli Valentina, Ianniciello Dolores, Letcher Sophia, Salvia Rosanna, Laginestra Ambrogio, Kaplan David L, Falabella Patrizia

机构信息

Department of Sciences University of Basilicata Via dell'Ateneo Lucano, 10 85100 Potenza Italy.

Spinoff Xflies S.R.L University of Basilicata Viale dell'Ateneo Lucano 10 85100 Potenza Italy.

出版信息

Small Sci. 2024 Jul 8;4(10):2400122. doi: 10.1002/smsc.202400122. eCollection 2024 Oct.

Abstract

The increasing global population and demand for meat have led to the need to find sustainable and viable alternatives to traditional production methods. One potential solution is cultivated meat (CM), which involves producing meat in vitro from animal stem cells to generate products with nutritional and sensory properties similar to conventional livestock-derived meat. This article examines current approaches to CM production and investigates how using insect cells could enhance the process. Cell sources are a critical issue in CM production, alongside advances in culture media, bioreactors for scalability, and scaffold development. Insect cells, compared to commonly used mammalian cells, may offer advantages in overcoming technological challenges that hinder cell culture development and expansion. The objective of this review is to emphasize how insects, as a cell source for CM production, could offer a more sustainable option. A crucial aspect for achieving this goal is a comprehensive understanding of the physiology of muscle and fat cells. In this work, the characteristics of insect and mammalian cells are compared, focusing particularly on muscle and fat cell development, regulatory pathways, hormonal regulation, and tissue composition. Insect cells are a promising source for CM, offering a sustainable and environmentally friendly alternative.

摘要

全球人口增长以及对肉类的需求不断增加,这使得有必要寻找可持续且可行的传统生产方式替代方案。一种潜在的解决方案是培养肉(CM),即从动物干细胞中体外生产肉类,以制造出营养和感官特性与传统家畜肉相似的产品。本文研究了当前培养肉生产的方法,并探讨了使用昆虫细胞如何能够改进这一过程。细胞来源是培养肉生产中的一个关键问题,同时还有培养基、用于扩大规模的生物反应器以及支架开发等方面的进展。与常用的哺乳动物细胞相比,昆虫细胞在克服阻碍细胞培养发展和扩大的技术挑战方面可能具有优势。这篇综述的目的是强调昆虫作为培养肉生产的细胞来源,如何能够提供一种更可持续的选择。实现这一目标的一个关键方面是全面了解肌肉和脂肪细胞的生理学。在这项工作中,对昆虫细胞和哺乳动物细胞的特性进行了比较,特别关注肌肉和脂肪细胞的发育、调控途径、激素调节以及组织组成。昆虫细胞是培养肉的一个有前景的来源,提供了一种可持续且环保的替代方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a1/11935034/954ba111e5de/SMSC-4-2400122-g006.jpg

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