McMahan Sara, Taylor Alan, Copeland Katherine M, Pan Zui, Liao Jun, Hong Yi
Department of Bioengineering, University of Texas at Arlington, Arlington, Texas.
College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas.
J Biomed Mater Res A. 2020 Apr;108(4):972-983. doi: 10.1002/jbm.a.36874. Epub 2020 Jan 12.
The number of people affected by heart disease such as coronary artery disease and myocardial infarction increases at an alarming rate each year. Currently, the methods to treat these diseases are restricted to lifestyle change, pharmaceuticals, and eventually heart transplant if the condition is severe enough. While these treatment options are the standard for caring for patients who suffer from heart disease, limited regenerative ability of the heart restricts the effectiveness of treatment and may lead to other heart-related health problems in the future. Because of the increasing need for more effective therapeutic technologies for treating diseased heart tissue, cardiac patches are now a large focus for researchers. The cardiac patches are designed to be integrated into the patients' natural tissue to introduce mechanical support and healing to the damaged areas. As a promising alternative, synthetic biodegradable polymer based biomaterials can be easily manipulated to customize material properties, as well as possess certain desired characteristics for cardiac patch use. This comprehensive review summarizes recent works on synthetic biodegradable cardiac patches implanted into infarcted animal models. In addition, this review describes the basic requirements that should be met for cardiac patch development, and discusses the inspirations to designing new biomaterials and technologies for cardiac patches.
受冠状动脉疾病和心肌梗死等心脏病影响的人数每年都以惊人的速度增长。目前，治疗这些疾病的方法仅限于改变生活方式、药物治疗，病情严重时最终进行心脏移植。虽然这些治疗选择是照顾心脏病患者的标准方法，但心脏有限的再生能力限制了治疗效果，未来可能会导致其他与心脏相关的健康问题。由于对治疗患病心脏组织的更有效治疗技术的需求不断增加，心脏贴片现在成为研究人员的一大重点。心脏贴片旨在整合到患者的天然组织中，为受损区域提供机械支持和愈合作用。作为一种有前途的替代方案，基于合成可生物降解聚合物的生物材料可以很容易地进行加工以定制材料特性，并且具有心脏贴片使用所需的某些特性。这篇综述总结了最近关于植入梗死动物模型的合成可生物降解心脏贴片的研究工作。此外，本综述描述了心脏贴片开发应满足的基本要求，并讨论了设计新型心脏贴片生物材料和技术的灵感来源。
