Department of Endocrinology, Xinhua Hospital Chongming Branch, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, China.
Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
BMC Endocr Disord. 2020 May 15;20(1):66. doi: 10.1186/s12902-020-00550-3.
The aim of this study was to estimate the levels of circulating carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in subjects with gestational diabetes mellitus (GDM) and investigate the relationships between CEACAM1 and GDM.
Circulating CEACAM1 levels were measured by ELISA kit in 70 women with GDM and 70 normal glucose tolerance (NGT) pregnant women. Blood samples were collected to detect fasting plasma glucose (FPG), fasting insulin (FINS) and glycosylated hemoglobin (HbA1c) levels in all participants. Insulin sensitivity index (ISOGTT) was calculated to assess insulin sensitivity. Correlation analysis was performed between serum CEACAM1 levels and other parameters.
Circulating CEACAM1 levels were higher in the GDM group than that in the NGT pregnant group, however, the difference showed no statistical significance (1889.82 ± 616.14 vs 1758.92 ± 433.15 pg/ml, p > 0.05). In GDM group, CEACAM1 was positively correlated with ISOGTT (R = 0.39, P = 0.001), while negatively with 1 h post-meal plasma insulin level (1hPINS) (R = -0.32, P = 0.008), 2 h post-meal plasma insulin level (2hPINS) (R = -0.33, P = 0.006) and area under curve of insulin (AUCI) (R = -0.36, P = 0.002) when adjusting for maternal age and gestational age.
The present study showed that circulating CEACAM1 levels did not differ in both GDM and NGT groups. However, we found a significant positively correlation between CEACAM1 and insulin sensitivity in the GDM group.
本研究旨在评估妊娠期糖尿病（GDM）患者循环中癌胚抗原相关细胞黏附分子 1（CEACAM1）的水平，并探讨 CEACAM1 与 GDM 之间的关系。
采用 ELISA 试剂盒检测 70 例 GDM 患者和 70 例正常糖耐量（NGT）孕妇的循环 CEACAM1 水平。所有参与者均采集血样检测空腹血糖（FPG）、空腹胰岛素（FINS）和糖化血红蛋白（HbA1c）水平。计算胰岛素敏感指数（ISOGTT）以评估胰岛素敏感性。对血清 CEACAM1 水平与其他参数之间的相关性进行分析。
GDM 组患者的循环 CEACAM1 水平高于 NGT 孕妇组，但差异无统计学意义（1889.82±616.14 vs 1758.92±433.15 pg/ml，p>0.05）。在 GDM 组中，CEACAM1 与 ISOGTT 呈正相关（R=0.39，P=0.001），与 1h 餐后血浆胰岛素水平（1hPINS）（R=-0.32，P=0.008）、2h 餐后血浆胰岛素水平（2hPINS）（R=-0.33，P=0.006）和胰岛素曲线下面积（AUCI）（R=-0.36，P=0.002）呈负相关，且以上相关性在调整母亲年龄和孕周后仍然存在。
本研究表明，GDM 和 NGT 组患者的循环 CEACAM1 水平无差异。然而，我们发现 GDM 组患者中 CEACAM1 与胰岛素敏感性呈显著正相关。
