Department of Medical Imaging Technology, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Neurol India. 2020 Mar-Apr;68(2):278-281. doi: 10.4103/0028-3886.284377.
The incidence and prevalence of Parkinson's (PD) are increasing rapidly in developing countries. PD is difficult to diagnose based on clinical assessment. Presently, magnetic resonance imaging (MRI) methods such as R2* and Quantitative Susceptibility Mapping (QSM) were found to be useful in diagnosing the PD based on the iron deposition in different regions of the brain. The objective of this review was to evaluate the efficacy of QSM over R2* in assessment of PD. A comprehensive literature search was made on PubMed-Medline, CINAHL, Science Direct, Scopus, Web of Science, and the Cochrane library databases for original research articles published between 2000 and 2018. Original articles that reported the efficacy of QSM and R2* in assessment of PD were included. A total of 327 studies were identified in the literature search. However, only ten studies were eligible for analysis. Of the ten studies, five studies compared the accuracy of QSM over R2* in measuring the iron deposition in different regions of brain in PD. Our review found that QSM has better accuracy in identifying iron deposition in PD patients compared to R2*. However, there is discrepancy in the results between MRI Imaging methods and Postmortem studies. Additional longitudinal research studies are needed to provide a strong evidence base for the use of MRI imaging methods such as R2*and QSM in accurately measuring iron deposition in different regions of brain and serve as biomarkers in PD.
帕金森病（PD）在发展中国家的发病率和患病率正在迅速上升。基于临床评估，PD 很难诊断。目前，磁共振成像（MRI）方法（如 R2和定量磁化率映射（QSM））已被发现可用于根据大脑不同区域的铁沉积来诊断 PD。本综述的目的是评估 QSM 在评估 PD 方面的效果优于 R2。在 2000 年至 2018 年期间，我们在 PubMed-Medline、CINAHL、Science Direct、Scopus、Web of Science 和 Cochrane 图书馆数据库中对原始研究文章进行了全面的文献检索。纳入了报告 QSM 和 R2在评估 PD 中的效果的原始文章。文献检索中确定了 327 项研究。但是，只有 10 项研究符合分析要求。在这 10 项研究中，有 5 项研究比较了 QSM 和 R2在测量 PD 患者大脑不同区域铁沉积方面的准确性。我们的综述发现，与 R2相比，QSM 在识别 PD 患者铁沉积方面具有更高的准确性。然而，MRI 成像方法和尸检研究之间的结果存在差异。需要进行额外的纵向研究，为 R2和 QSM 等 MRI 成像方法在准确测量大脑不同区域铁沉积方面提供有力的证据基础，并作为 PD 的生物标志物。
